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Variability and predictability of the plasma concentration of ampicillin and kanamycin in new-born infants

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Summary

The variability and predictability of the plasma concentration of ampicillin and kanamycin in new-born infants being treated for infections are discussed. For kanamycin a standard dose regimen of 7.5 mg/kg/12 h is recommended.

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References

  1. Driessen, O. M. J., Sorgedrager, N., Michel, M. F., Kerrebijn, K. F., Hermans, J.: Pharmacokinetic aspects of therapy with ampicillin and kanamycin in new-born infants. Europ. J. clin. Pharmacol.13, 449–457 (1978)

    Google Scholar 

  2. Gladtke, E., Van Hattingberg, H. M.: Pharmacokinetik. Eine Einführung. Berlin, Heidelberg, New York: Springer 1973

    Google Scholar 

  3. Huber, J. P., Nelson, J. D.: Re-evaluation of kanamycin dosage in infants and children. Antimicrob. Agents Chemother.9, 899–902 (1976)

    Google Scholar 

  4. Howard, J. B., McCracken, G. H.: Reappraisal of kanamycin usage in neonates. J. Pediatr.86, 949–956 (1975)

    Google Scholar 

  5. Simon, H., Axline, S.: Clinical pharmacology of kanamycin in premature infants. Ann. N. Y. Acad. Sci.132, 1020–1025 (1966)

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University of Leiden, The Netherlands

    O. M. J. Driessen

  2. Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands

    N. Sorgedrager & K. F. Kerrebijn

  3. Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands

    M. F. Michel

  4. Department of Medical Statistics, University of Leiden, The Netherlands

    J. Hermans

Authors
  1. O. M. J. Driessen
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  2. N. Sorgedrager
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  3. M. F. Michel
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  4. K. F. Kerrebijn
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  5. J. Hermans
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Driessen, O.M.J., Sorgedrager, N., Michel, M.F. et al. Variability and predictability of the plasma concentration of ampicillin and kanamycin in new-born infants. Eur J Clin Pharmacol 15, 133–137 (1979). https://doi.org/10.1007/BF00609877

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  • DOI: https://doi.org/10.1007/BF00609877

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