Summary
In order to characterize the β-adrenoceptor subtype of the venous vessel wall, venous occlusion plethysmograph studies were carried out in 7 healthy volunteers. Venous distensibility (VD) was considered to be a measure of venous tone. Infusion of the β1- and β2-adrenoceptor agonist isoproterenol (I), of the predominantly β2-adrenoceptor agonist fenoterol (F) and of the predominantly β1-adrenoceptor agonist dobutamine (D) in increasing doses led to a significant increase in VD by I and F but not by D. Administration of the β1-adrenoceptor antagonists betaxolol (B) and metoprolol (M) did not significantly change VD. Neither β-adrenoceptor antagonist prevented the increase in VD provoked by subsequent administration of I or F. It is concluded that β-adrenoceptors in the venous vessel wall belong to the β2-adrenoceptor subtype.
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Dedicated to Professor K. D. Bock for his 60th birthday
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Weber, F., Anlauf, M. Beta-adrenoceptor subtype of the venous capacity system: Characterization by venous occlusion plethysmography. Eur J Clin Pharmacol 28, 139–142 (1985). https://doi.org/10.1007/BF00609681
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DOI: https://doi.org/10.1007/BF00609681