Summary
In chloralose-anaesthetized dogs hepatic blood flow and hepatic O2 consumption were determined under control conditions and during infusion of large amounts of lactic acid buffered to pH 7.4. The amounts of lactic acid were selected to correspond to those produced during heavy muscular exercise.
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1.
Hepatic blood flow was found to be in the order of 27±8 ml/kg body weight or 157±50.5 ml/min×100 g liver.
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2.
Hepatic oxygen consumption amounted to 8.1±2.1 ml/min×100 g liver.
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3.
Lactate infusion resulted in an increased O2 consumption of the liver which was linear with lactate extraction.
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4.
This increase of hepatic O2 consumption corresponded well to the O2 consumption of the whole animal.
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5.
32±8% of infused lactate was extracted by the liver. Oxidation of the remaining 70% is not reflected in the increased O2 consumption of the whole animal. It must therefore be oxidized preferentially in place of normally burned substances.
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6.
It is concluded that the so called “lactacid O2-debt” is only partly explained by hepatic oxidation of lactic acid processes. The major part is unexplained.
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Kramer, K., Driessen, G., Brechtelsbauer, H. et al. Lactate elimination and O2 consumption of the liver in narcotized dogs. Pflugers Arch. 330, 195–205 (1971). https://doi.org/10.1007/BF00588611
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DOI: https://doi.org/10.1007/BF00588611