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Effects of plasmapheresis on renal hemodynamics and sodium excretion in dogs

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Summary

Acute plasmapheresis in dogs reduces plasma protein concentration, without significantly altering plasma volume, glomerular filtration rate and plasma sodium concentration.

The effects of acute hypoproteinemia on renal circulation is variable. In some cases, the renal plasma flow is not modified, while in others it is markedly decreased, leading to a rise in filtration fraction. The hemodynamic changes are observed in experiments inducing marked protein depletion.

Acute hypoproteinemia increases sodium excretion exclusively in experiments where plasmapheresis has not reduced kidney irrigation.

The lack of plasma volume expansion in the natriuretic animals cancels the necessity of postulating the secretion of some unknown natriuretic hormone to explain the decreased tubular reabsorption of sodium. The explanation of “saline diuresis” should be sought within the kidney itself, and the fall in peritubular oncotic pressure, occurring after plasmapheresis or during massive saline loading, offers an alternative explanation, which appears simpler and more rational.

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References

  1. Bahlmann, J., S. J. McDonald, J. G. Dunningham, andH. E. de Wardener: The effect on urinary sodium excretion of altering the packed cell volume with albumin solutions without changing the blood volume in the dog. Clin. Sci.32, 395 (1967).

    Google Scholar 

  2. Bahlmann, J., S. J. McDonald, M. G. Ventom, andH. E. de Wardener: The effect on urinary sodium excretion of blood volume expansion without changing the composition of blood in the dog. Clin. Sci. 403 (1967).

  3. Bonsnes, R. W., andH. H. Taussky: On the colorimetric determination of creatinine by the Jaffe reaction. J. biol. Chem.158, 581 (1945).

    Google Scholar 

  4. Bresler, E. H.: The problem of the volume component of body fluid homeostasis. Amer. J. med. Sci.232, 93 (1956).

    Google Scholar 

  5. Chinard, F. P., andH. A. Eder: The determination of the concentration of the dye T-1824 in normal and lipemic patients. J. exp. Med.87, 473 (1948).

    Google Scholar 

  6. Cizek, L.J., andM. B. Zucker: Effect of hypoproteinemia produced by plasmapheresis on plasma and interstitial fluid volumes and renal clearances of dogs. Amer. J. Physiol.162, 153 (1950).

    Google Scholar 

  7. Cortney, M. A., M. Mylle, E. E. Lassiter, andC. W. Gottschalk: Renal tubular transport of water solute and PAH in rats loaded with isotonic saline. Amer. J. Physiol.209, 1199 (1965).

    Google Scholar 

  8. Crawford, B., andH. Ludemann: The renal reponse to intravenous injection of sodium chloride solutions in man. J. clin. Invest.30, 1456 (1951).

    Google Scholar 

  9. de Wardener, H. E., I. H. Mills, W. F. Clapham andC. J. Hayter: Studies on the afferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin. Sci.21, 249 (1961).

    Google Scholar 

  10. Dirks, J. H., W. J. Cirksena, andR. W. Berliner: The effect of saline infusion on sodium reabsorption by the proximal tubule of the dog. J. clin. Invest.44, 1160 (1965).

    Google Scholar 

  11. Earley, L. E.: Effect of renal arterial infusion of albumin on saline diuresis in the dog. Proc. Soc. exp. (N. Y.)116, 262 (1964).

    Google Scholar 

  12. —, andR. M. Friedler: The effects of combined renal vasodilation and pressor agents on renal hemodynamics and the tubular reabsorption of sodium. J. clin. Invest.45, 542 (1966).

    Google Scholar 

  13. —,J. A. Martino, andR. M. Friedler: Factors affecting sodium reabsorption by the proximal tubule as determined during blockade of distal sodium reabsorption. J. clin. Invest.45, 1668 (1966).

    Google Scholar 

  14. Elpers, M. J., andE. E. Selkurt: Effects of albumin infusion on renal function in the dog. Amer. J. Physiol.205, 153 (1963).

    Google Scholar 

  15. Goodyer, A. V. N., E. R. Peterson, andA. S. Relman: Some effects of albumin infusions on renal function and electrolyte excretion in normal man. J. appl. Physiol.1, 671 (1949).

    Google Scholar 

  16. Gornall, A. G., C. J. Bardawil, andH. H. David: Determination of serum proteins by means of biuret reaction. J. biol. Chem.177, 751 (1949).

    Google Scholar 

  17. Harsing, L., G. Köver, M. Mályusz, G. Tóth u.T. Harza: Die Wirkung von vasodilatorischen Substanzen (Papaverin, Acetylcholin) auf die Nierenfunktion. Pflügers Arch. ges. Physiol.281, 346 (1964).

    Google Scholar 

  18. Harvey, R. B.: Effects of acetylcholine infused into renal artery of dogs. Amer. J. Physiol.211, 487 (1966).

    Google Scholar 

  19. Hayslett, J. P., M. Kashgarian, andF. H. Epstein: Changes in proximal and distal tubular reabsorption produced by rapid expansion of extracellular fluid. J. clin. Invest.46, 1254 (1967).

    Google Scholar 

  20. Jacobson, W. E., J. F. Hammarsten, andB. I. Heller: The effects of adrenaline upon renal function and electrolyte excretion. J. clin. Invest.20, 1503 (1951).

    Google Scholar 

  21. Keys, A.: The study of colloidal dimensions, thermodynamic activity and the mean molecular weight of the mixed proteins in blood serum. J. phys. Chem.42, 11 (1938).

    Google Scholar 

  22. Levinsky, N. G., andR. C. Lalone: The mechanism of sodium diuresis after saline loading: evidence for a factor other than increased filtered sodium and decreased aldosterone. J. clin. Invest.42, 1261 (1963).

    Google Scholar 

  23. Lewy, J. E., andE. E. Windhager: Peritubular control of proximal tubular fluid reabsorption in the rat kidney. Amer. J. Physiol.214, 943 (1968).

    Google Scholar 

  24. McSmythe, C., J. E. Nickel, andS. E. Bradley: The effect of epinephrine (USP), l-epinephrine and l-norepinephrine on glomerular filtration rate, renal plasma flow and the urinary excretion of sodium, potassium and water in normal man. J. clin. Invest.31, 499 (1952).

    Google Scholar 

  25. Martino, J. A., andL. E. Earley: Demonstration of a role of physical factors as determinants of the natriuretic response to volume expansion. J. clin. Invest.46, 1963 (1967).

    Google Scholar 

  26. Meyer, M. B., andL. I. Goldberg: Natriuretic effect of papaverine. Fed. Proc.24, 258 (1965).

    Google Scholar 

  27. Mills, I. H., H. E. de Wardener, C. J. Hayter, andW. F. Clapham: Studies on the afferent mechanism of the sodium chloride diuresis which follows intravenous saline in the dog. Clin. Sci.21, 259 (1961).

    Google Scholar 

  28. Nizet, A.: Excretion of water and sodium loading by isolated perfused dog kidney. Pflügers Arch. ges. Physiol.297, 156 (1967).

    Google Scholar 

  29. Petersdorf, R. G., andL. G. Welt: The effect of an infusion of hyperoncotic albumin on the excretion of water and solutes. J. clin. Invest.32, 283 (1953).

    Google Scholar 

  30. Pinter, G. G., C. C. C. O'Morchoe, andR. S. Sikand: Effect of acetylcholine on urinary electrolyte excretion. Amer. J. Physiol.207, 979 (1964).

    Google Scholar 

  31. Rector, F. C., Jr., M. Martinez-Maldonado, N. A. Kurtzman, J. C. Sellman, F. Oerther, andD. W. Seldin: Demonstration of a hormonal inhibitor of proximal tubular reabsorption during expansion of extracellular volume with isotonic saline. J. clin. Invest.47, 761 (1968).

    Google Scholar 

  32. —,G. Vangiesen, F. Kill, andD. W. Seldin: Influence of expansion of extracellular volume on tubular reabsorption of sodium, independent of changes in glomerular filtration rate and aldosterone activity. J. clin. Invest.43, 341 (1964).

    Google Scholar 

  33. Shuster, A., E. A. Elexander, R. C. Lalone, andN. G. Levinsky: Renal blood flow sodium excretion and concentrating ability during saline infusion. Amer. J. Physiol.211, 1181 (1966).

    Google Scholar 

  34. Smith, H. W., N. Finkelstein, L. Aluminosa, B. Crawford, andM. Graber: The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man. J. clin. Invest.24, 388 (1945).

    Google Scholar 

  35. Snedecor, G. W.: Statistical methods, 5th edition, p. 291. Iowa State University Press, Amer., Iowa (1956).

    Google Scholar 

  36. Stein, R. M., D. D. Bercovitch, andM. F. Levitt: Dual effects of saline loading on renal tubular sodium reabsorption in the dog. Amer. J. Physiol.207, 826 (1964).

    Google Scholar 

  37. Vander, A. J.: Effects of acetylcholine, atropine and physostigmine on renal function in the dog. Amer. J. Physiol.206, 492 (1964).

    Google Scholar 

  38. Vereerstraeten, P., andM. de Myttenaere: Effect of raising the transtubular oncotic gradient on sodium excretion in the dog. Pflügers Arch.302, 1 (1968).

    Google Scholar 

  39. — etP. P. Lambert: Réduction de la natriurèse par la perfusion de protéines dans l'artère rénale du chien. Nephron3, 103 (1966).

    Google Scholar 

  40. — andC. Toussaint: Role of the peritubular oncotic pressure on sodium excretion by the avian kidney. Pflügers Arch.302, 13 (1968).

    Google Scholar 

  41. Vogel, G., u.E. Heym: Untersuchungen zur Bedeutung kolloidosmotischer Druckdifferenzen für den Mechanismus der isoosmotischen Flüssigkeitsreabsorption in der Niere. Pflügers Arch. ges. Physiol.262, 226 (1956).

    Google Scholar 

  42. Watson, J. F.: Effect of saline loading on sodium reabsorption in the dog proximal tubule. Amer. J. Physiol.210, 781 (1966).

    Google Scholar 

  43. Welt, L. G., andJ. Orloff: The effects of an increase in plasma volume on the metabolism and excretion of water and electrolytes by normal subjects. J. clin. Invest.30, 751 (1951).

    Google Scholar 

  44. Williams, R. L., J. E. Pearson, Jr., andM. K. Carter: The saluretic effects of arecoline hydrochloride infused into the left renal artery of dogs. J. Pharmacol. exp. Ther.147, 32 (1965).

    Google Scholar 

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  1. Laboratoire de Médecine expérimentale, Université Libre de Bruxelles et Fondation Médicale Reine Elisabeth, Bruxelles, Belgium

    P. Vereerstraeten & C. Toussaint

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  1. P. Vereerstraeten
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  2. C. Toussaint
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Vereerstraeten, P., Toussaint, C. Effects of plasmapheresis on renal hemodynamics and sodium excretion in dogs. Pflugers Arch. 306, 92–102 (1969). https://doi.org/10.1007/BF00586613

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