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Hand, foot and mouth disease

Light and Electron Microscopic Observations

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Summary

Virus Coxsackie Group A, Type 5 was isolated from the content of vesicles obtained from the soles of two girls with Hand, Foot and Mouth disease. The vesicles are located intra-epidermally. Neither inclusion bodies nor giant cells were observed. Electron microscopic studies revealed intranuclear electron-dense particles surrounded by a membrane within the nucleus. These particles, presumably RNA viruses, have not been previously reported within the nucleus of epidermal cells.

Zusammenfassung

Bei zwei Mädchen mit Hand-Fuß-Mund-Krankheit, wurde das Coxsackievirus, Gruppe A, Typ 5 im Inhalt der Blasen, die sich auf der Fußsohle befanden, isoliert. Die Blasen lagen intraepidermal. Es wurden weder Einschlußkörper noch Riesenzellen festgestellt. Die Untersuchungen mit dem Elektronenmikroskop zeigten elektronendichte Partikel, die von einer Membran umgeben waren und sich in dem Kern der Zellen fanden. In der Literatur wurden diese Partikel in Kernen von Epidermiszellen bisher noch nicht beschrieben. Es handelt sich sehr wahrscheinlich um RNA-Viren.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, Mendoza, Argentina

    Cristóbal A. Parra

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  1. Cristóbal A. Parra
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Parra, C.A. Hand, foot and mouth disease. Arch. Derm. Forsch. 245, 147–153 (1972). https://doi.org/10.1007/BF00584517

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  • DOI: https://doi.org/10.1007/BF00584517

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