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Lethal no-differentiation and the development of the imaginal discs during the larval stage inDrosophilia

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Summary

  1. 1.

    Lethal no-differentiation, symboll-nd, is characterised by the failure of some or all of the imaginal buds to continue differentiation during the larval third instar. This is due to abnormal proliferation of the imaginal disc mesoderm.

  2. 2.

    There is a well-defined sequence in the sensitivity of the different organs to the lethal effect, the legs being the most commonly affected, and the genital disc the least commonly.

  3. 3.

    The abnormal proliferation of the mesoderm is preceded by degenerative changes in the lymph glands.

  4. 4.

    The mechanism of differentiation of the imaginal buds is discussed and it is argued that the organisation of the imaginal organs is determined primarily by the mesoderm.

  5. 5.

    It is suggested that the proliferation of the imaginal bud mesoderm is normally inhibited by a “bud-differentiation hormone” secreted by the lymph glands. The requirements of the different imaginal discs from this postulated hormone were represented by a histogram, in fig. 14.

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Abbreviations

AD :

abdomen

DP :

disc proper

EY :

eye

HEX :

melanised hexagons

HD :

head

HT :

halter

LG :

legs

LGD :

leg buds

MES :

mesoderm

MP :

mouth parts

PC :

peripodial cavity

PM :

peripodial membrane

RD :

ruptured disc proper

SG :

salivery glands

SP :

spheroids

TH :

thorax

WG :

wings

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Authors and Affiliations

  1. Institute of Animal Genetics, Edinburgh University, Scotland

    H. H. El Shatoury

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  1. H. H. El Shatoury
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El Shatoury, H.H. Lethal no-differentiation and the development of the imaginal discs during the larval stage inDrosophilia . W. Roux' Archiv f. Entwicklungsmechanik 147, 523–538 (1955). https://doi.org/10.1007/BF00576002

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  • DOI: https://doi.org/10.1007/BF00576002

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