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Acute hypotensive action of clonidine after intravenous infusion in hypertensive emergencies

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Summary

Clonidine was administered by intravenous infusion to 12 patients classified as having exaggerated arterial hypertension, their systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressures were significantly reduced from the third min. The maximal percentage reduction (Mean±SEM) reached 30.1±3.1% (SAP) and 24.7±2.9% (DAP) after 30 to 110 min of infusion. Initially there were transitory initial increases in SAP (3 patients) and DAP (1 patient). The increases in blood pressure were related to low body surface area (BSA). The dose of clonidine per m2 BSA able to reduce by 10% either SAP or DAP (active dose-10), and the dose able to reduce SAP or DAP by 10 mmHg in one minute (systolic or diastolic clonidine unit) were calculated, providing indices for detecting clonidine responsiveness in patients with exaggerated hypertension. This method is advantageous when using clonidine intravenously because it diminishes the risk of overdosage.

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Authors and Affiliations

  1. Hypertension Unit, Department of Internal Medicine, Hospital Universitario de Caracas, Luis Razetti Medical School and Bioanalysis School, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela

    F. Pérez-Acuña, P. Monsalve, J. Pérez, A. Tremarias, A. Sanabria & F. Fragachán

Authors
  1. F. Pérez-Acuña
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  2. P. Monsalve
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  3. J. Pérez
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  4. A. Tremarias
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  5. A. Sanabria
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  6. F. Fragachán
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Pérez-Acuña, F., Monsalve, P., Pérez, J. et al. Acute hypotensive action of clonidine after intravenous infusion in hypertensive emergencies. Eur J Clin Pharmacol 25, 151–155 (1983). https://doi.org/10.1007/BF00543784

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  • DOI: https://doi.org/10.1007/BF00543784

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