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Biotransformation of amitriptyline in alcoholic depressive patients

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Summary

The biotransformation of amitriptyline (AMT) during steady state conditions was studied in plasma and urine from 11 nonalcoholic and 10 alcoholic depressive inpatients treated with oral AMT. The 2 groups of patients had a different pattern of biotransformation. The Demethylation of AMT was lower in alcoholic than in nonalcoholic depressive patients, and conjugation and hydroxylation of AMT were also more marked in the former group. The results may be of clinical relevance since the conjugates of AMT are inactive.

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Authors and Affiliations

  1. Laboratoire de Pharmacologie Clinique, Centre Hospitalier Universitaire, Besancon, France

    M. Sandoz, S. Vandel & B. Vandel

  2. Clinique de Neurologie et Psychiatrie, Centre Hospitalier Universitaire, Besancon, France

    B. Bonin, G. Allers & R. Volmat

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  1. M. Sandoz
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  2. S. Vandel
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  3. B. Vandel
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  4. B. Bonin
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  5. G. Allers
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  6. R. Volmat
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Sandoz, M., Vandel, S., Vandel, B. et al. Biotransformation of amitriptyline in alcoholic depressive patients. Eur J Clin Pharmacol 24, 615–621 (1983). https://doi.org/10.1007/BF00542210

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  • DOI: https://doi.org/10.1007/BF00542210

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