Zusammenfassung
Die im obigen Titel erwähnten, vier biologisch unentbehrlichen Brenzcatechin-Amine besitzen eine sarkomhemmende Fähigkeit. Die Hemmung wird durch Cupri-Ionen bedeutend verstärkt. Unter Mitwirkung von Kupfer können diese o-Diphenol-Verbindungen Nucleinsäuren depolymerisieren und das DNS-Molekül spezifisch an der Stelle des Pyrimidin-Nucleotid-Kluster brechen. Die Ergebnisse wurden im Zusammenhang mit der metabolischen Tumor-Regression oder Cancerisation und ferner dem cellulare Differenzierung und Anomalisation verursachenden Yamafuji-Effekt kurz diskutiert.
Summary
Four biologically essential catecholamines mentioned in above title are able to inhibit sarcoma growth; the inhibition is greatly enhanced by cupric ions. In combination with copper, these o-diphenol compounds depolymerize nucleic acids and break the DNA-molecule specically at the site of pyrimidine nucleotide cluster. The results were briefly discussed in relation to metabolic tumour regression or cancerization and further to Yamafuji effect causing cellular differentiation and anomalization.
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References
Dische, Z., Devi, A.: A new colorimetric method for the determination of ketohexoses in presence of aldoses, ketoheptoses and ketopentoses. Biochim. biophys. Acta (Amst.) 39, 140 (1960).
Goulian, M., Kornberg, A., Sinsheimer, R. L.: Enzymatic synthesis of DNA, XXIV. Synthesis of infectious phage X174 DNA. Proc. nat. Acad. Sci. (Wash.) 58, 2321 (1967).
Habermann, V., Habermannova, S., Cerhova, M.: The distribution of nucleotides into pyrimidine and purine nucleotide clusters in the polynucleotide chain of DNA from Escherichia coli C. Biochim. biophys. Acta (Amst.) 76, 310 (1963).
Okamoto, K., Mudd, J. A., Marmur, J.: Conversion of Bacillus subtilis DNA to phage DNA following mitomycin C induction. J. molec. Biol. 34, 429 (1968).
Takemura, S.: Hydrazinolysis of nucleic acid, I. The formation of deoxyriboapyrimidinic acid from herring sperm DNA. Bull. Chem. Soc. Japan 32, 920 (1959).
Tamm, C., Hodes, M. E., Chargaff, E.: The formation of apurinic acid from the deoxyribonucleic acid of calf thymus. J. biol. Chem. 195, 49 (1952).
Wu, R., Kaiser, A. D.: Structure and base sequence in the cohesive ends of bacteriophage Lambda DNA. J. molec. Biol. 35, 523 (1968).
Yamafuji, K.: Metabolic virogens having mutagenic action and chromosomal previruses (Review). Enzymologia 27, 217 (1964).
—: Isolation of polyhedral pre-viral deoxyribonucleic acid and mode of action of virogens. Agric. Biochem. Kyushu Univ. 26, 1 (1965).
—: An effect causing mutagenesis, virogenesis, carciogenesis and cancer degression. Agric. Biochem. Kyushu Univ. 28, 1 (1968).
—, Hashinaga, F.: Isolation of a pre-viral deoxyribonucleic acid. Nature (Lond.) 210, 1158 (1966).
——: Hybridization between polyhedral viral and previral deoxyribonucleic acid. Enzymologia 32, 364 (1967).
Yamafuji, K., Murakami, H.: Antitumour potency of lignin and pyrocatechol and their action on deoxyribonucleic acid. Enzymologia 35, 139 (1968).
—, Shirozu, Y.: Die Abhängigkeit der Neubildung des Virusproteins von der Erniedrigung der Katalase. Biochem. Z. 317, 94 (1944).
—, Uchida, Y.: Effect of some mutagenic virogens and carcinogens on deoxyribonucleic acid. Enzymologia 35, 131 (1968).
—, Watanabe, K.: Mutagenic action of hyponitrous acid and glucose oxime. Nature (Lond.) 203, 409 (1964).
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Yamafuji, K., Murakami, H. & Shinozuka, M. Antitumour activity of dopa, dopamine, noradrenalin or adrenalin and their reaction with nucleic acids. Z Krebs-forsch 73, 195–203 (1970). https://doi.org/10.1007/BF00524398
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DOI: https://doi.org/10.1007/BF00524398