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A new locus regulating the expression of the Ldh-2 gene in mouse liver

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Abstract

Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-banded one. Immunochemical evidence was obtained indicating that differences in the LDH pattern are mainly due to different contents of the B subunit of LDH. Linkage tests indicated that the locus Ldr-2 determining the amounts of the LDH B subunit in mouse liver tissue is located in chromosome 6, 19 ± 4.1 cm away from the earlier described Ldr-1 locus. The effect of locus Ldr-2 is strictly tissue-specific; it is manifest only on days 6–8 after birth.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch of Academy of Sciences of the USSR, Novosibirsk-90, USSR

    T. M. Khlebodarova & O. L. Serov

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  1. T. M. Khlebodarova
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  2. O. L. Serov
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Khlebodarova, T.M., Serov, O.L. A new locus regulating the expression of the Ldh-2 gene in mouse liver. Biochem Genet 18, 1027–1039 (1980). https://doi.org/10.1007/BF00500133

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  • DOI: https://doi.org/10.1007/BF00500133

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