Summary
Three tryptophan catabolites (tryptophol, indoleacetic acid and indoleacetaldehyde) were identified in the extracellular broths of deregulated mutants but not in that of the wild type. These compounds resulted from the degradation of excess tryptophan formed by the deregulated mutants. The mutants also produced 2 to 3 nonindolic compounds. Tryptophan was a minor product; tryptophol, the major broth metabolite. Among the deregulated strains, there were differences not only in the relative proportions but also in the spectra of the compounds produced. Tryptophol, indoleacetic acid and indoleacetaldehyde were produced by resting cells from added tryptophan or tryptamine. The presence of nonindolic compounds in the tryptophan-supplemented, but not tryptamine-supplemented, resting cell systems suggests that Hansenula polymorpha can degrade tryptophan by multiple pathways.
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Denenu, E.O., Demain, A.L. Relationship between genetic deregulation of Hansenula polymorpha and production of tryptophan metabolites. European J. Appl. Microbiol. Biotechnol. 13, 202–207 (1981). https://doi.org/10.1007/BF00500098
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DOI: https://doi.org/10.1007/BF00500098