Summary
We investigated the effect of (+)-amphetamine on body temperature in the unrestrained and curarized rat. In the unrestrained animal kept at an ambient temperature of 30°C amphetamine had a dose-dependent hyperthermic action, whereas in animals kept at 7°C it decreased body temperature. An increase in body temperature was evident also in the curarized rat; after spinal cord transection at the level of C1; and in the pithed rat. Pretreatment with the alpha-adrenergic blocking agent azapetine attenuated amphetamine-hyperthermia in the curarized rat, but enhanced the hyperthermic response in the unrestrained rat. Pretreatment with the beta-adrenergic blocking agent propranolol abolished amphetamine-hyperthermia in the curarized rat, but did not affect the response in the unrestrained animal. In the hypophysectomized animal amphetamine had a hypothermic effect even at high ambient temperatures. It is concluded that the action of amphetamine on peripheral beta-receptors has a hyperthermic effect, but that additional mechanisms are involved in the thermal response of the freely moving animal.
References
Borbély, A. A.: Telemetry of body temperature, motor activity, food and fluid intake in the rat, in: Proceedings of the 4th International Congress in Pharmacology, Vol. 5, p. 295. Basel: Schwabe 1970
Brodie, B. B., Cho, A. K., Stefano, F. J. E., Gessa, G. L.: On mechanisms of norepinephrine release by amphetamine tyramine and tolerance to their effects. Advanc. Biochem. Psychopharmacol. 1, 219–232 (1969)
Brodie, B. B., Davies, J. I., Hynie, S., Krishna, G., Weiss, B.: Interrelationships of catecholamines with other endocrine systems. Pharmacol. Rev. 18, 273–289 (1966)
Brown, A. M., Julian, T.: The body temperature response of two inbred strains of mice to handling, saline and amphetamine. Int. J. Neuropharmacol. 7, 531–541 (1966)
Cahn, J., Herold, M.: Effects of amphetamine in rats and rabbits injected with alpha and beta-adrenergic blocking agents. In: Amphetamines and related compounds. E. Costa and S. Garattini, Eds., pp. 493–510. New York: Raven Press 1970
Coper, H., Lison, H., Rommelspacher, H., Schulze, G., Strauss, S.: The influence of adrenergic receptor-blocking agents, amphetamine and 6-aminonicotinamide on thermoregulation. Naunyn-Schmiedebergs Arch. Pharmak. 270, 378–391 (1971)
Cripps, H., Dearnaley, D. P., Howe, P. R. C.: Enhancement of noradrenaline depletion in the cat spleen by phenoxybenzamine and phentolamine Brit. J. Pharmacol. 46, 358–365 (1972)
Enero, U. A., Langer, S. Z., Rothlin, R. P., Stefano, F. J. E.: Role of the α-adrenoceptor in regulating noradrenaline overflow by nerve stimulation. Brit. J. Pharmacol. 44, 672–688 (1972)
Farnebo, L. O., Hamberger, B.: Effects of desipramine, phentolamine and phenoxybenzamine on the release of noradrenaline from isolated tissue. J. Pharm. Pharmacol. 22, 855–857 (1970)
Gessa, G. L., Clay, G. A., Brodie, B. B.: Evidence that hyperthermia produced by d-amphetamine is caused by a peripheral action of the drug. Life Sci. I, 8, 135–141 (1969)
Goodman, H. M.: Permissive effects of hormones on lipolysis. Endocrinology 86, 1064 (1970)
Graf, H., Borbély, A.: Radiotelemetrische Körpertemperaturmessung bei Mäusen und Ratten. Experientia (Basel) 22, 339–340 (1966)
Greenblatt, D. J., Shader, R. I.: On the psychopharmacology of beta adrenergic blockade. Curr. ther. Res. 14, 615–625 (1972)
Himms-Hagen, J.: Adrenergic receptors for metabolic responses in adipose tissue. Fed. Proc. 29 1388–1401 (1970)
Marks, B. H., Hall, M. M., Bhattachary, A. N.: Psychopharmacological effects and pituitary-adrenal activity. In: Pituitary, adrenal and the brain. Progress in brain research, Vol. 32, pp. 57–70. D. De Wied and J. A. W. M. Weijnen, Eds. Amsterdam: Elsevier 1970
Matsumoto, C., Shaw, W. N.: The involvement of plasma free fatty acid in (+)-amphetamine-induced hyperthermia in rats. J. Pharm. Pharmacol. 23, 387–388 (1971)
Morpurgo, C., Theobald, W.: Pharmacological modification of the amphetamine-induced hyperthermia in rats. Europ. J. Pharmacol. 2, 287–294 (1967)
Randall, L. O., Smith, T. H.: The adrenergic blocking action of some dibenzazepine derivatives. J. Pharmacol. exp. Ther. 103, 10–23 (1951)
Robison, G. A., Langley, P. E., Burns, T. W.: Adrenergic receptors in human adipocytes-divergent effects on adenosine 3′,5′-monophosphate and lipolysis. Biochem. Pharmacol. 21, 589–592 (1972)
Reid, W. D.: Turnover rate of brain 5-hydroxytryptamine increased by d-amphetamine. Brit. J. Pharmacol. 40, 483–491 (1970)
Spengler, J.: Ein Apparat zur quantitativen Registrierung der Nahrungs- und Wasseraufnahme bei Ratten. Helv. physiol. pharmacol. Acta 18, 50–55 (1960)
Strubelt, O.: Die kalorigene und positiv chronotrope Wirkung sympathicomimetischer Amine und ihre Beeinflussung durch Blockade der adrenergischen β-Rezeptoren. Arzneimittel-Forsch. 16, 587–592 (1966)
Strubelt, O., Lubenau, W.: Vergleichende Untersuchungen über den Einfluß von Propranolol, Chlorpromazin und Urethan auf die Thermoregulation der Ratte. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 353–364 (1966)
Waser, P. G.: Calebassen-Curare. Helv. physiol. pharmacol. Acta, Suppl. 8, 1–84 (1953)
Yehuda, S., Wurtman, R. J.: The effects of d-amphetamine and related drugs on colonic temperatures of rats kept at various ambient temperatures. Life Sci. I, 11, 851–859 (1972)
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Borbély, A.A., Baumann, I.R. & Waser, P.G. Amphetamine and thermoregulation: Studies in the unrestrained and curarized rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 281, 327–340 (1974). https://doi.org/10.1007/BF00499429
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DOI: https://doi.org/10.1007/BF00499429