Abstract
Plasma volume was measured using Evans blue dye and 125iodinated human serum albumin (RIHSA) simultaneously in order to evaluate the accuracy of a simplified Evans blue method recommended by Nielsen and Nielsen (1962). 9 studies were performed in 8 newborn infants weighing 1.07 to 2.85 kg and 16 studies in 14 patients aged 6 months to 14 years suffering from severe circulatory disturbances. In 20 studies, plasma volumes measured by Evans blue and by RIHSA agreed within ±5%, and in all the studies within ±10%. The Evans blue method yielded higher plasma volumes than the RIHSA method in 19 instances. The mean difference (paired t-test) was only significant in newborn infants (+4.0±3.6%; P<0.05). The disappearance rates of Evans blue exceeded that of RIHSA in 16 studies, but this was only significant in the patients older than 6 months (+2.3±4.2%/h; P<0.05).
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Linderkamp, O., Mader, T., Butenandt, O. et al. Plasma volume estimation in severely ill infants and children using a simplified Evans blue method. Eur J Pediatr 125, 135–141 (1977). https://doi.org/10.1007/BF00489986
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DOI: https://doi.org/10.1007/BF00489986