Skip to main content
Log in

Membranpermeation und Antibiotika-Resistenz bei Bakterien

  • Published:
Naturwissenschaften Aims and scope Submit manuscript

Abstract

The resistance of mainly gram-negative bacteria against antibiotics is discussed with respect to new discoveries on the permeability barrier of the outer membrane. Proteins originally characterized as virus receptors have been found to be involved in the translocation of certain substrates across the membrane. Antibiotics can reach their target by the same “pores”.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Goebel, W.: Angew. Chem. 85, 569 (1973)

    Google Scholar 

  2. Richmond, M.H., in: Progr. Nucleic Acid Research 1973

  3. Sheratt, D.J.: Cell 3, 189 (1974)

    Google Scholar 

  4. Benveniste, R., Davis, J.: Ann. Rev. Biochem. 42, 471 (1973)

    Google Scholar 

  5. Wise, E.M., Abou-Donai, M.M.: Proc. Natl. Acad. Sci. USA 72, 2621 (1975)

    Google Scholar 

  6. Sköld, O., With, A.: J. Biol. Chem. 249, 4324 (1974)

    Google Scholar 

  7. Amyes, S.G.B., Smith, J.T.: Biochem. Biophys. Res. Commun. 58, 412 (1974)

    Google Scholar 

  8. Connamacher, R.H., in: Hahn, F.E.: Acquired Resistance of Microorganisms to Chemotherapeutic Drugs. Basel: S. Karger 1976

    Google Scholar 

  9. Levy, S.B., McMurray, L.: Biochem. Biophys. Res. Commun. 56, 1060 (1974)

    Google Scholar 

  10. Franklin, T.J.: CRC Crit. Rev. Microbiol. 30, 253 (1973)

    Google Scholar 

  11. Zähner, H., Maas, W.K.: Biology of Antibiotics. Heidelberg: Springer 1972

    Google Scholar 

  12. Lackner, H.: Angew. Chem. 87, 400 (1975)

    Google Scholar 

  13. Wargel, R.J., Shadur, C.A., Neuhaus, F.C.: J. Bacteriol. 103, 778 (1970)

    Google Scholar 

  14. Diddens, H., et al.: Eur. J. Biochem. 66, 11 (1976)

    Google Scholar 

  15. Kenig, M., Abraham, E.P.: J. Gen. Microbiol. 94, 37 (1976)

    Google Scholar 

  16. Zimmermann, W., Knüsel, F.: Arch. Mikrobiol. 68, 107 (1969)

    Google Scholar 

  17. Hantke, K., Braun, V.: FEBS Lett. 49, 301 (1975)

    Google Scholar 

  18. Braun, V., et al.: J. Supramolec. Struct. 5, 37 (1976)

    Google Scholar 

  19. Lin, E.C.C.: Ann. Rev. Genet. 4, 225 (1970)

    Google Scholar 

  20. Komatsu, Y., Tanaka, K.: Biochim. Biophys. Acta 288, 390 (1972)

    Google Scholar 

  21. Plakunow, V.K.: Antibiotiki 18, 1069 (1973)

    Google Scholar 

  22. Braun, V., et al.: J. Bacteriol. 114, 1264 (1973)

    Google Scholar 

  23. Braun, V., Hantke, K.: Ann. Rev. Biochem. 43, 89 (1974)

    Google Scholar 

  24. Archibald, A.R., Baddiley, J., Heckels, J.E.: Nature New Biol. 241, 29 (1973)

    Google Scholar 

  25. Birdsell, D.C., Doyle, R.J., Morgenstern, M.: J. Bacteriol. 121, 726 (1975)

    Google Scholar 

  26. Braun, V.: Biochim. Biophys. Acta 415, 335 (1975)

    Google Scholar 

  27. Smit, J., Kamio, Y., Nikaido, H.: J. Bacteriol. 124, 942 (1975)

    Google Scholar 

  28. Garten, W., Hindenach, J., Henning, U.: Eur. J. Biochem. 59, 215 (1975)

    Google Scholar 

  29. Schnaitman, C.A.: J. Bacteriol. 118, 442 (1974)

    Google Scholar 

  30. Haller, J., Hoehn, B., Henning, U.: Biochemistry 14, 478 (1975)

    Google Scholar 

  31. Mühlradt, P.F., et al.: Eur. J. Biochem. 43, 553 (1974)

    Google Scholar 

  32. Schlecht, S., Westphal, O.: Zbl. Bakt. Paras. Infekt. Abt. I Orig. 213, 356 (1970)

    Google Scholar 

  33. Tamaki, S., Sato, T., Matsuhashi, M.: J. Bacteriol. 105, 968 (1971)

    Google Scholar 

  34. Monner, D., Jonsson, S., Boman, H.G.: ibid. 107, 420 (1971)

    Google Scholar 

  35. Nikaido, H.: Biochim. Biophys. Acta 433, 118 (1976)

    Google Scholar 

  36. Taubeneck, U.: Nature 196, 195 (1962)

    Google Scholar 

  37. Leive, L., Shovlin, V.K., Mergenhagen, S.E.: J. Biol. Chem. 243, 6384 (1968)

    Google Scholar 

  38. Roantree, R.J., et al.: Clin. Res. 17, 157 (1969)

    Google Scholar 

  39. Koplow, J., Goldfine, H.: J. Bacteriol. 117, 527 (1974)

    Google Scholar 

  40. Ames, G.F.-L., Spudich, E.N., Nikaido, H.: ibid. 117, 406 (1974)

    Google Scholar 

  41. Kamio, Y., Nikaido, H.: Biochemistry 15, 2561 (1976)

    Google Scholar 

  42. Braun, V., et al.: Eur. J. Biochem. 62, 555 (1976)

    Google Scholar 

  43. Nakae, T., Nikaido, H.: J. Biol. Chem. 250, 7359 (1975)

    Google Scholar 

  44. Rosenbusch, J.P.: ibid. 249, 8019 (1974)

    Google Scholar 

  45. Nakae, T.: ibid. 251, 2176 (1976)

    Google Scholar 

  46. Smelcman, S., Hofnung, M.: J. Bacteriol. 124, 112 (1975)

    Google Scholar 

  47. Smelcman, S., et al.: Eur. J. Biochem. 65, 13 (1976)

    Google Scholar 

  48. Weinberg, E.D.: Science 184, 952 (1974)

    Google Scholar 

  49. Rogers, H.J., in: Schlesinger, D.: Microbiology 1974. Washington, D.C.: Amer. Soc. Microbiol. 1975

    Google Scholar 

  50. Neilands, J.B.: Microbial Iron Metabolism. New York: Academic Press 1974

    Google Scholar 

  51. Hantke, K., Braun, V.: FEBS Lett. 59, 277 (1976)

    Google Scholar 

  52. Hancock, R.E.W., Braun, V.: ibid. 65, 208 (1976)

    Google Scholar 

  53. Hancock, R.E.W., Hantke, K., Braun, V.: J. Bacteriol. 127, 1370 (1976)

    Google Scholar 

  54. Pugsley, A.O., Reeves, P.: Biochem. Biophys. Res. Commun. 70, 846 (1976)

    Google Scholar 

  55. McIntosh, M.A., Earhart, C.F.: ibid. 70, 315 (1976)

    Google Scholar 

  56. Luckey, M., et al.: J. Bacteriol. 111, 731 (1972)

    Google Scholar 

  57. Lelong, J., Neilands, J.B.: ibid. 126, 823 (1976)

    Google Scholar 

  58. Fickel, T.E., Gilvarg, Ch.: Nature New Biol. 241, 161 (1973)

    Google Scholar 

  59. Hantke, K.: FEBS Lett. 70, 109 (1976)

    Google Scholar 

  60. Bradbeer, C., Woodrow, M.L., Khalifah, L.I.: J. Bacteriol. 125, 1032 (1976)

    Google Scholar 

  61. Hantke, K., Braun, V.: Virology 58, 310 (1974)

    Google Scholar 

  62. Phillips, S.K., Cramer, W.A.: Biochemistry 12 1170 (1973)

    Google Scholar 

  63. Poljak, R.J.: Nature 256, 373 (1975)

    Google Scholar 

  64. Richards, F.F., et al.: Science 187, 130 (1975)

    Google Scholar 

  65. Helmreich, E.J.M.: FEBS Lett. 61, 1 (1976)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Braun, V. Membranpermeation und Antibiotika-Resistenz bei Bakterien. Naturwissenschaften 64, 126–132 (1977). https://doi.org/10.1007/BF00450570

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00450570

Navigation