Abstract
Effects of ginsenoside Rg1 (Rg1), a major component of panax ginseng, on modulation of ingestive behavior were investigated. No direct effect was observed on food intake after 10 μl infusion of 1.0, 2.0, 4.0 or 8.0 mM Rg1 into the rat third ventricle for 10 min. Continuous osmotic infusion of 4.0 mM Rg1 at a rate of 0.966 μl/h into the third ventricle prevented feeding suppression caused by surgical procedure to implant an osmotic minipump. Continuous infusion of Rg1 attenuated anorexia, increased water intake, and decreased ambulation, that were produced by elevation of environmental temperature from 21° C to 30° C. Consequently, rats maintained body weight and rectal temperature unchanged. The results indicate that sustained central administration of Rg1 may relieve anorexia caused by implantation surgery or by a heated environment.
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Arase K, Sakaguchi T, Takahashi M, Bray GA, Ling N (1987) Effects on feeding behavior of rats of a cryptic peptide from the C-terminal end of prepro-growth hormone-releasing factor. Endocrinology 121:1960–1965
Chen JYP (1984) Pharmacological actions and therapeutic uses of Ginseng (Panax ginseng) (Angelica sinensis). Int J Chin Med 1:23–27
Cormarèche-Leydier M (1984) The effects of long warm and cold ambient exposures on food intake and water intake and body weight in the capsaicin desensitized rat. Pflugers Arch 400:183–187
Davies RF (1977) Long- and short-term regulation of feeding patterns in the rat. J Comp Physiol Psychol 91:574–585
Etou H, Sakata T, Fujimoto K, Terada K, Yoshimatsu H, Ookuma K, Hayashi T, Arichi S (1988) Ginsenoside-Rb1 as a suppressor in central modulation of feeding in the rat. Folia Pharmacol Japon 91:9–15
Fujimoto K, Sakata T, Shiraishi T, Kurata K, Terada K, Etou H (1986) Anorexia induced in rat by D-glucosamine deoxidized at C-1. Am J Physiol 251:R481-R491
Hamilton CL (1967) Food and temperature. In: Code CF (ed) Handbook of physiology: section 6: alimentary canal, vol I: control of food and water intake. Am Physiol Soc, Washington, DC, pp 303–317
Hamilton CL, Brobeck JR (1964) Food intake and temperature regulation in rats with rostral hypothalamic lesions. Am J Physiol 207:291–297
Hori T, Tsuzuki S (1981) Thermoregulation in adult rats which have been treated with capsaicin as neonates. Pflugers Arch 390:219–223
Iida Y, Tanaka O, Shibata S (1968) Studies on saponins of ginseng: the structure of ginsenoside-Rg1. Tetrahedron Lett 52:5449–5453
Joo CN (1987) Proceedings of Korea-Japan Panax Ginseng Symposium. The Society for Korean Ginseng, Seoul
Kita T, Hata T, Kawashima Y, Kaku T, Itoh E (1981) Pharmacological actions of ginseng saponin in stress mice. J Pharm Dyn 4:381–393
Masuno H, Yoshimura H, Ogawa N, Okuda H (1984) Isolation of a lipolytic factor (toxohormone-L) from ascites fluid of patients with hepatoma and its effect on feeding behavior. Eur J Cancer Clin Oncol 20:1177–1185
Sakata T, Fukushima M, Tsutsui K, Arase K, Fujimoto K (1982) Theophylline disrupts diurnal rhythms of humoral factors with loss of meal cyclicity. Physiol Behav 28:641–647
Sakata T, Fujimoto K, Terada K, Arase K, Fukushima M (1984) Changes in meal pattern and endogenous feeding related substances following mazindol administration. Arch Int Pharmacodyn Ther 270:11–28
Sakata T, Fujimoto K, Fukushima M, Terada K, Arase K (1985) 1-Deoxy-glucosamine initiates, then effectively suppresses feeding in the rat. Physiol Behav 34:969–972
Sakata T, Etou H, Fujimoto K, Ookuma K, Hayashi T, Arichi S (1987) Central effects of ginsenosides on the feeding behavior and response to stress in rats. Korean J Ginseng Sci 11:164–172
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Fujimoto, K., Sakata, T., Ishimaru, T. et al. Attenuation of anorexia induced by heat or surgery during sustained administration of ginsenoside Rg1 into rat third ventricle. Psychopharmacology 99, 257–260 (1989). https://doi.org/10.1007/BF00442819
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DOI: https://doi.org/10.1007/BF00442819