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D-Amphetamine in obsessive-compulsive disorder

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Abstract

In a double-blind rossover study, single doses of d-amphetamine and placebo were administered to 12 patients with severe chronic obsessive-compulsive disorder (OCD). Improvement of obsessional symptoms was significant on clinical ratings and was correlated with improved performance on an attention task. Changes were also significant for self-rated measures of activation and altered reality. The behavioral response to amphetamine was not statistically correlated with subsequent improvement during a 6-week clomipramine trial, although the direction of change was the same during both treatments for every patient studied.

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Authors and Affiliations

  1. Clinical Neuropharmacology Branch, National Institutes of Mental Health, 20205, Bethesda, MD, USA

    Thomas R. Insel, Jean A. Hamilton, Laurence B. Guttmacher & Dennis L. Murphy

Authors
  1. Thomas R. Insel
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  2. Jean A. Hamilton
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  3. Laurence B. Guttmacher
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  4. Dennis L. Murphy
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Insel, T.R., Hamilton, J.A., Guttmacher, L.B. et al. D-Amphetamine in obsessive-compulsive disorder. Psychopharmacology 80, 231–235 (1983). https://doi.org/10.1007/BF00436159

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  • DOI: https://doi.org/10.1007/BF00436159

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