Abstract
The pharmacologic profile of flutroline, a tetrahydro-γ-carboline compound, predicts and antipsychotic compound with greater potency and longer duration than established clinical antipsychotic compounds. In normal male volunteers, it elicited EEG, behavioral, and plasma prolactin release profiles similar to established antipsychotic compounds. Peak activity occurred in 4–5 h. But the clinical activity projected from these studies is one-fifth that of haloperidol. In relation to the available clinical findings, the pharmaco-EEG data are better predictors of the clinical activity of flutroline than its preclinical profile.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fink M (1969) EEG and human psychopharmacology. Ann Rev Pharmacol 9:241–258
Fink M (1978) EEG and psychopharmacology. In: Cobb WA, Duijn H van (eds) Contemporary clinical neurophysiology (Suppl 34). Electroenceph Clin Neurophysiol 45:41–56
Fink M, Irwin P (1979) CNS effects of the antihistamines diphenhydramine and terfenadine (RMI 9918). Pharmakopsychiat 12:35–44
Fink M, Irwin P, Gastpar M, de Ridder H (1977) EEG, blood level, and behavioral effects of the antidepressant mianserin (ORG GB 94). Psychopharmacology 54:249–254
Fink M, Irwin P, Sannita W, Papakostas Y, Green MA (1979) Phenytoin: EEG effects and plasma levels in volunteers. Ther Drug Monitoring 1:93–104
Fink M, Irwin P, Sibony P (1975) EEG classification of a novel anorexigenic: PRF-36-CL. Comparison with placebo, dextroamphetamine, and fenfluramine. In: Sudilovsky A, Gershon S, Beer B (eds) Predictiveness in psychopharmacology: Preclinical and clinical correlations Raven Press, New York, p 65
Fink M, Irwin P, Weinfeld R, Schwartz M, Conney A (1976) Blood levels and EEG effects of diazepam and bromazepam. Clin Pharmacol Ther 20:184–191
Hollister L (1978) Clinical pharmacology of psychotherapeutic drugs. Churchill Livingstone, New York, p 239
Honigfeld G, Klett C (1965) The nurse's observation scale for inpatient evaluation (NOSIE): A new scale for measuring improvement in chronic schizophrenia. J Clin Psychol 21:65–71
Koe BK, Weissman A, Plattner JJ, Harbert CA, Welch WM (1979) Potent dopamine (DA) receptor blockade by a structurally novel neuroleptic: 8-fluoro-5-p-fluorophenyl-2-(4-hydroxy-4-p-fluorophenylbutyl)-1,2,3,4-tetrahydro-γ-carboline (CP-36,584). Pharmacologist 21:180
Meltzer HY, Fang VS (1976) The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch gen Psychiatry 33:279–286
Meltzer HY, Piyakalmala S, Schyve P, Fang VS (1977) Lack of effect of tricyclic antidepressants on serum prolactin levels. Psychopharmacology 51:185–187
Overall JE, Gorham DR (1962) The brief psychiatric rating scale. Psychol Rpt 10:799–812
Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York, p 907
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fink, M., Irwin, P. EEG and behavioral profile of flutroline (CP-36,584), a novel antipsychotic drug. Psychopharmacology 72, 67–71 (1980). https://doi.org/10.1007/BF00433808
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00433808