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Small doses of apomorphine induced catalepsy and antagonize methamphetamine stereotypy in rats

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Abstract

Small doses of apomorphine (AP, 31.25–125 μg/kg IP) induced dose-dependent catalepsy in rats. However. unlike the stereotyped behavior induced by high doses of AP which has a rapid onset and is short-lasting, the cataleptic effect induced by small doses of AP was evident 30 min after AP injection and was unusually long-lasting. Further, AP (31.25–125 μg/kg) administered 60 min before methamphetamine was found to significantly antagonize the methamphetamine-induced stereotyped behavior. Pretreatment with molindone (0.45 and 0.8 mg/kg IP), in doses reported to selectively block the presynaptic DA receptors, not only decreased the cataleptic effect of AP but also reversed the AP antagonism of methamphetamine stereotypy. The results suggest that small doses of AP induce catalepsy and antagonize methamphetamine stereotypy probably by an action at presynaptic DA receptor sites.

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References

  • Ålander T, Grabowska-Andén M, Andén NE (1980) Physiological significance of dopamine autoreceptors as studied following their selective blockade by molindone. J Pharm Pharmacol 32:780–782

    Google Scholar 

  • Carlsson A (1975) Receptor-mediated control of dopamine metabolism. In: Usdin E, Bunney WE (eds) Pre- and postsynaptic receptors. Marcel Dekker, New York, pp 49–65

    Google Scholar 

  • Carroll BJ, Curtis GC, Kokmen E (1977) Paradoxical rosponse to dopamine agonists in tardive dyskinesia. Am J Psychiatry 134:785–789

    Google Scholar 

  • Costall B, Fortune DH, Hui SCG, Naylor RJ (1980) Neuroleptic antagonism of the motor inhibitory effects of apomorphine within the nucleus accumbens: Drug interaction at presynaptic receptors? Eur J Pharmacol 63:347–358

    Google Scholar 

  • Costall B, Naylor RJ (1973) On the mode of action of apomorphine. Eur J Pharmacol 21:350–361

    Google Scholar 

  • Costall B, Naylor RJ (1974) Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol 27:46–58

    Google Scholar 

  • DiChiara G, Corsini GU, Mereu GP, Tissari A, Gessa GL (1978) Self-inhibitory dopamine receptors: Their role in the biochemical and behavioral effects of low doses of apomorphine. In: Roberts PJ, Woodruff GN, Iversen LL (eds) Dopamine. Raven, New York, pp 275–292

    Google Scholar 

  • DiChiara G, Porceddu ML, Vargiu L, Argiolas A, Gessa GL (1976) Evidence for dopamine receptors mediating sedation in the mouse brain. Nature 264:564–567

    Google Scholar 

  • Hornykiewicz O (1975) Parkinsonism induced by dopaminergic antagonists. In: Calne DB, Chase TN, Barbeau A (eds) Dopaminergic mechanisms. Raven, New York, pp 155–164

    Google Scholar 

  • Klawans HL, Goetz C, Westheimer R (1976) The pharmacology of schizophrenia. In: Klawans HL (ed) Clinical neuropharmacology, vol 1. Raven, New York, pp 1–28

    Google Scholar 

  • Martres MP, Costentin J, Baudry M, Marcais H, Protais P, Schwartz JC (1977) Long-term changes in the sensitivity of pre- and postsynaptic dopamine receptors in mouse striatum evidenced by behavioral and biochemical studies. Brain Res 136:319–337

    Google Scholar 

  • Pycock CJ, Horton RW, Carter CJ (1978) Interactions of 5-hydroxytryptamine and γ-aminobutyric acid with dopamine. In: Roberts PJ, Woodruff GN, Iversen LL (eds) Dopamine. Raven, New York, pp 323–341

    Google Scholar 

  • Strömbom U (1976) Catecholamine receptor agonists: Effects on motor activity and rate of tyrosine hydroxylation in mouse brain. Naunyn-Schmiedebergs Arch Pharmacol 262:167–176

    Google Scholar 

  • Strömbom U (1977) Antagonism by haloperidol of locomotor depression induced by small doses of apomorphine. J Neural Transm 40:191–194

    Google Scholar 

  • Tamminga CA, Schaffer MH, Smith RC, Davis JM (1978) Schizophrenic symptoms improve with apomorphine. Science 200:567–568

    Google Scholar 

  • Tolosa ES, Sparber SB (1975) Apomorphine in Huntington's chorea: Clinical observations and theoretical considerations. Life Sci 15:1371–1380

    Google Scholar 

  • Wallach MB (1974) Drug-induced stereotyped behaviour: Similarities and differences. In: Usdin E (ed) Neuropsychopharmacology of monoamines and their regulatory enzymes. Raven, New York, pp 241–260

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, V. M. Medical College, 413003, Solapur (Maharashtra), India

    J. J. Balsara, T. R. Bapat, V. P. Gada & A. G. Chandorkar

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  1. J. J. Balsara
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  2. T. R. Bapat
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  3. V. P. Gada
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  4. A. G. Chandorkar
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Balsara, J.J., Bapat, T.R., Gada, V.P. et al. Small doses of apomorphine induced catalepsy and antagonize methamphetamine stereotypy in rats. Psychopharmacology 78, 192–194 (1982). https://doi.org/10.1007/BF00432262

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  • DOI: https://doi.org/10.1007/BF00432262

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