Abstract
Methane oxidation by washed cell suspensions of Methylosinus trichosporium OB3B was selectively inhibited by 25 compounds, including metal binding components such as carbon monoxide (85% O2: 15% CO), KCN (10-6 M), αα′-dipyridyl (10-4 M), 8-quinolinol (10-4 M), thiosemicarbazide (10-5 M), thiourea (10-5 M), hydroxylamine (10-4 M), histidine (10-2 M), British Anti-Lewisite (5x10-3 M), and miscellaneous known inhibitors of other oxygenases. A role for copper in the methane oxygenase system was suggested by the pattern of inhibition and relief of inhibition by added metal ions.
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Hubley, J.H., Thomson, A.W. & Wilkinson, J.F. Specific inhibitors of methane oxidation in Methylosinus trichosporium . Arch. Microbiol. 102, 199–202 (1975). https://doi.org/10.1007/BF00428369
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DOI: https://doi.org/10.1007/BF00428369