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A histochemical study of bone marrow hypoplasia in anorexia nervosa

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Summary

The bone marrow in patients with anorexia nervosa is commonly hypoplastic with transformation of marrow fat. The normal fat cells which appear clear and open in the marrow are surrounded by an amorphous, gelatinous material, thought to represent an increase in the ordinary acid mucopolysaccharide ground substance of the bone marrow. Since this lesion has a similar appearance grossly and microscopically to the lesion of serous fat atrophy found in cachectic patients, we have compared the histochemical properties of this amorphous material in a bone marrow from a patient with anorexia nervosa and from cachectic patients with epicardial serous fat atrophy and with the background substance in hypoplastic marrows. Both this fat-associated deposition in the bone marrow and serous fat atrophy were found to be predominantly a hyaluronic acid mucopolysaccharide. In contrast, the background substance contained a less acid mucopolysaccharide. The increase in bone marrow acid mucopolysaccharide in anorexia nervosa may represent a serous fat atrophy change rather than an increase in ground substance.

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References

  • Bauermeister, D.E.: Quantitation of bone marrow reticulin — a normal range. Amer. J. clin. Path. 56, 24–31 (1971)

    Google Scholar 

  • Keys, A., Brozek, J., Henschel, A., Mickelsen, O., Taylor, H.L.: The biology of human starvation, Vol. I, pp. 258–261. Minneapolis: University of Minnesota Press 1950

    Google Scholar 

  • Luna, L.G., ed.: Manual of histologic staining methods of the Armed Forces Institute of Pathology, third edit., pp. 163–164. New York: McGraw-Hill 1968

    Google Scholar 

  • Mant, M.J., Faragher, B.S.: The hematology of anorexia nervosa. Brit. J. Haemat. 23, 737–749 (1972)

    Google Scholar 

  • Pearson, H.A.: Marrow hypoplasia in anorexia nervosa. J. Pediat. 71, 211–215 (1967)

    Google Scholar 

  • Putt, F.A.: Manual of histopathological staining methods, pp. 162–163. New York: John Wiley & Sons 1972

    Google Scholar 

  • Seidensticker, J.F., Tzagournes, M.: Anorexia nervosa — clinical features and long-term follow-up. J. chron. Dis. 21, 361–367 (1968)

    Google Scholar 

  • Wintrobe, M.M.: Clinical hematology, ed. 5, p. 65. Philadelphia: Lea and Febiger 1961

    Google Scholar 

  • Zugibe, F.T.: Diagnostic histochemistry, p. 300. St. Louis: Mosby 1970

    Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Pathology, Department of Pathology, University of California, San Diego, La Jolla, California

    P. Joanne Cornbleet, Robert C. Moir & Paul L. Wolf M.D.

Authors
  1. P. Joanne Cornbleet
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  2. Robert C. Moir
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  3. Paul L. Wolf M.D.
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Cornbleet, P.J., Moir, R.C. & Wolf, P.L. A histochemical study of bone marrow hypoplasia in anorexia nervosa. Virchows Arch. A Path. Anat. and Histol. 374, 239–247 (1977). https://doi.org/10.1007/BF00427118

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  • DOI: https://doi.org/10.1007/BF00427118

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