Abstract
An examination of the severity of tardive dyskinesia in psychiatric inpatients using the Abnormal Involuntary Movement Scale (AIMS) indicates differing trends with age for each sex. Females show a significant linear increase with age, while males display a significant curvilinear relationship. Reliable differences between males and females are found only for the 70–79 and ≥80 year age groups. The differences between the sexes cannot be accounted for by differences in length of current hospitalization or by current level of neuroleptic medication. Possible reasons for the results are discussed.
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References
American College of Neuropsychopharmacology: Neurological syndromes associated with antipsychotic drug use. Arch. Gen. Psychiatry 28, 463–466 (1973)
Brandon, S., McClelland, H. A., Protheroe, C.: A study of facial dyskinesia in a mental hospital population. Br. J. Psychiatry 118, 171–184 (1971)
Crane, G. E.: Tardive dyskinesia in schizophrenic patients treated with psychotropic drugs. Agressologie 9, 209–216 (1968)
Crane, G. E., Paulson, G.: Involuntary movements in a sample of chronic mental patients and their relation to the treatment with neuroleptics. Int. J. Neuropsychiatry 3, 286–291 (1967)
Dincmen, K.: Chronic psychotic choreo-athetosis. Dis. Nerv. Syst. 27, 399–402 (1966)
Fann, W. E., Davis, J. M., Janowsky, D. S.: The prevalence of tardive dyskinesias in mental hospital patients. Dis. Nerv. Syst. 33, 182–186 (1972)
Fracchia, J., Sheppard, C., Merlis, S.: Combination medications in psychiatric treatment: patterns in a group of elderly hospital patients. J. Am. Geriatr. Soc. 19, 301–307 (1971)
Guy, W.: ECDEU assessment manual for psychopharmacology-revised 1976. Washington, D.C.: DHEW 1976
Kazamatsuri, H., Chien, C.-P., Cole, J. O.: Therapeutic approaches to tardive dyskinesia. Arch. Gen. Psychiatry 27, 491–499 (1972)
Kennedy, P. F., Hershon, H. I., McGuire, R. J.: Extrapyramidal disorders after prolonged phenothiazine therapy. Br. J. Psychiatry 118, 509–518 (1971)
Klawans, H. L., Jr.: The pharmacology of tardive dyskinesias. Am. J. Psychiatry 130, 82–86 (1973)
Laska, E., Varga, E., Wanderling, J., Simpson, G., Logemann, G. W., Shah, B. K.: Patterns of psychotropic drug use for schizophrenia. Dis. Nerv. Syst. 34, 294–305 (1973)
Mettler, F. A., Crandell, A.: Neurologic disorders in psychiatric institutions. J. Nerv. Ment. Dis. 128, 148–159 (1959)
Prien, R. F., Haber, P. A., Caffey, E. M.: The use of psychoactive drugs in elderly patients with psychiatric disorders: survey conducted in twelve veterans administration hospitals. J. Am. Geriatr. Soc. 23, 104–112 (1975)
Samorajski, T.: Central neurotransmitter substances and aging: a review. J. Am. Geriatr. Soc. 25, 337–348 (1977)
Sheppard, C., Collins, L., Fiorentino, D., Fracchia, J., Merlis, S.: Polypharmacy in psychiatric treatment: incidence at a state hospital. Curr. Ther. Res. 11, 765–774 (1969)
Siede, H., Müller, H. F.: Choreiform movements as side effects of phenothiazine medication in geriatric patients. J. Am. Geriatr. Soc. 15, 517–522 (1967)
Turunen, S., Achté, K. A.: The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy. Psychiatr. Q. 41, 268–279 (1967)
Winer, B. J.: Statistical principles in experimental design. New York: McGraw-Hill 1962
Wyatt, R. J.: Biochemistry and schizophrenia (part IV). The neuroleptics-their mechanism of action: a review of the biochemical literature. Psychopharmacol. Bull. 12, 5–50 (1976)
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Smith, J.M., Oswald, W.T., Kucharski, L.T. et al. Tardive dyskinesia: Age and sex differences in hospitalized schizophrenics. Psychopharmacology 58, 207–211 (1978). https://doi.org/10.1007/BF00426909
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DOI: https://doi.org/10.1007/BF00426909