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Attenuation of stereotyped behaviour by sex steroids

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Abstract

Effects of sex steroids, testosterone, progesterone, and estradiol on PEA-induced stereotyped behaviour (SB) has been studied in normal, castrated, and ovariectomised mice. Effects of sex steroids on amphetamine-induced stereotypy and hyperactivity are also described. In castrated and ovariectomised mice B-phenylethylamine (PEA) increased SB. Pretreatment with sex steroids attenuated PEA-induced stereotypy in normal, castrated, and ovarietomised mice. Sex steroid pretreatment significantly inhibited PEA- and amphetamine-induced SB, but failed to alter increased motor activity due to amphetamine or PEA. The possible effect of sex steroids on SB through changes in central neurotransmitters are discussed.

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Authors and Affiliations

  1. Pharmacological Research Unit, CSIR, Department of Pharmacology, Seth G.S. Medical College, Parel, 400012, Bombay, India

    S. R. Naik, M. R. Kelkar & U. K. Sheth

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  1. S. R. Naik
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  2. M. R. Kelkar
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  3. U. K. Sheth
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Naik, S.R., Kelkar, M.R. & Sheth, U.K. Attenuation of stereotyped behaviour by sex steroids. Psychopharmacology 57, 211–214 (1978). https://doi.org/10.1007/BF00426890

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  • DOI: https://doi.org/10.1007/BF00426890

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