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Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration

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Abstract

Previous studies have demonstrated that long-term administration of d-amphetamine produces a progressive augmentation of behavior. In the present experiment, rats receiving repeated systemic injections responded to an intraventricular infusion of d-amphetamine with an augmented increase in locomotor activity. These results indicate that central mechanisms, rather than peripheral dispositional factors, subserve the enhanced behavioral response to repeated amphetamine administration.

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Author notes

  1. George V. Rebec

    Present address: Department of Psychology, Indiana University, 47401, Bloomington, IN, U.S.A.

Authors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of California at San Diego, 92093, La Jolla, California, U.S.A.

    George V. Rebec & David S. Segal

Authors
  1. George V. Rebec
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  2. David S. Segal
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Rebec, G.V., Segal, D.S. Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration. Psychopharmacology 62, 101–102 (1979). https://doi.org/10.1007/BF00426043

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  • DOI: https://doi.org/10.1007/BF00426043

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