Skip to main content
SpringerLink
Log in

Drug resistance plasmids

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Conclusion

The discovery of chemotherapeutic agents brought remarkable progress to the practice of medicine and to human and animal hygiene. In addition, improved sanitation and preventive medicine have protected human beings from infectious diseases caused by known pathogenic bacteria. As a result, the types of bacteria that play leading roles in infectious diseases have changed. These microoganisms readily cause infection, they are parasitic, and they carry multiple drug resistance as a result of the use of chemotherapeutic agents. Thus, mutiply resistant organisms have become prevalent and particular strains have become stabilized in hospitals and farms.

The presence of conjugative (R) and nonconjugative (r) resistance plasmids in these bacterial strains has compounded the problems for the practice of medicine, livestock hygiene, and the fish culture industry. Rapid acquisition of drug resistance by bacteria and delays in finding new drugs have created new biological hazards for human beings.

The discovery of resistance plasmids opened new research fields in genetics and molecular biology; it became clear that multiply resistant bacteria could develop quickly and spread rapidly all over the world. The genes governing replication, self-regulation, conjugal transmission and drug resistance, including transposon, are the most fascinating problems in biology. And the prevalence of drug resistance plasmids has broadened our perspective on the role that genetic exchanges play in the natural history of bacterial species.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ochiai, K., Yamanaka, K., Kimura, K. and Sawada, O., 1959. Nihon Iji Shimpo No. 1861, 34–46.

  2. Akiba, T., Koyama, T., Isshiki, Y., Kimura, S. and Fukushima, T., 1960. Nihon Iji Shimpo No. 1886, 45–50.

  3. Davis, B. D., 1950. J. Bacteriol. 60, 507–508.

    Google Scholar 

  4. Mitsuhashi, S., Harada, K. and Hashimoto, H., 1960. Japan. J. Exp. Med. 30, 179–184.

    Google Scholar 

  5. Mitsuhashi, S., Hashimoto, H., Harada, K., Suzuki, M., Kameda, M. and Matsuyama, T., 1960 Japan. J. Bacteriol 15, 844–848.

    Google Scholar 

  6. Mitsuhashi, S., Harada, K. and Kameda, M., 1960. Tokyo Iji Shinshi 77, 462.

    Google Scholar 

  7. Mitsuhashi, S., Harada, K. and Kameda, M., 1961. Nature 189, 947.

    Google Scholar 

  8. Mitsuhashi, S., 1960. Science (Tokyo) 30, 628–633.

    Google Scholar 

  9. Mitsuhashi, S., 1977 in R factor-Drug Resistance Plasmid (Mitsuhashi, S., editor) pp 3–48, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

    Google Scholar 

  10. Mitsuhashi, S., 1979 in Epidemiology of Bacterial Resistance (Mitsuhashi, S., editor) pp 6–15, Kodansha; Academic Press, Tokyo and New York.

    Google Scholar 

  11. Mitsuhashi, S., 1979 ibid. pp. 83–90.

  12. Mitsuhashi, S., Morimura, M., Kono, M. and Oshima, H., 1963 J. Bacteriol. 86, 162–163.

    Google Scholar 

  13. Mitsuhashi, S., Hashimoto, H., Kono, M., and Morimura, M., 1965 J. Bacteriol. 89, 988–992.

    Google Scholar 

  14. Novick, R. P., 1963 J. Gen. Microbiol. 33, 121–136.

    Google Scholar 

  15. Mitsuhashi, S., Oshima, H., Kawarada, U. and Hashimoto, H., 1965 J. Bacteriol. 89, 967–976.

    Google Scholar 

  16. Mitsuhashi, S., Inoue, M., Kawabe, H., Oshima, H. and Okubo, T., 1973 in Staphylococci and Staphylococcal Infections (Jeljaszewicz, J. editor) pp 144–165, Karger, Basel.

    Google Scholar 

  17. Inoue, M., Okubo, T., Oshima, H. and Mitsuhashi, S., 1975. in Microbial drug resistance (Mitsuhashi, S. and Hashimoto, H. editors) pp 153–164, University of Tokyo Press, Tokyo and University Park Press, Baltimore and London.

  18. Inoue, M. and Mitsuhashi, S., 1979. in Epidemiology of Bacterial Resistance (Mitsuhashi, S., editor) pp 19–29, Kodansha and Academic Press, Tokyo and New York.

  19. Nakae, M., Inoue, M. and Mitsuhashi, S., 1976. Antimicrob. Agents. Chemother. 7, 719–720.

    Google Scholar 

  20. Courvalin, P., Calier, C. and Chabbert, Y., 1972. Ann. Inst. Pasteur (Paris) 123, 755–759.

    Google Scholar 

  21. Clewell, D. B., Yagi, Y., Dunny, G. and Schultz, S., 1974 J. Bacteriol. 117, 283–289.

    Google Scholar 

  22. Yagi, Y. and Clewell, D. B., 1976 J. Mol. Biol. 102, 583–600.

    Google Scholar 

  23. Yagi, Y. and Clewell, D. B., 1977 J. Bacteriol. 129, 400–406.

    Google Scholar 

  24. Dunny, G., Birch, N., Hascall, G. and Clewell, D. B., 1973 J. Bacteriol. 114, 1362–1364.

    Google Scholar 

  25. Lovett, P. S. and Bramucci, M. G., 1975 J. Bacteriol. 124, 484–490.

    Google Scholar 

  26. Bernhard, K., Schrempf, H. and Goebel, W., 1978. J. Bacteriol. 133, 897–903.

    Google Scholar 

  27. Saito, T., Fuse, A., Inoue, M. and Mitsuhashi, S., 1979. J. Bacteriol. in press.

  28. Smith, H. R., Humphrey, G. O. and Anderson, E. S., 1974. Mol. Gen. Genet. 129, 229–242.

    Google Scholar 

  29. Brath, P. and Grinter, N. J., 1974. J. Bacteriol. 120, 618–630.

    Google Scholar 

  30. Mitsuhashi, S., Inoue, K. and Inoue, M., 1977 Antimicrob. Agents Chemother. 12, 418–422.

    Google Scholar 

  31. Inoue, M., Inoue, K. and Mitsuhashi, S., 1979. J. Bacteriol. in press.

  32. Nakahara, H., Ishikawa, T., Saraai, Y. Kono, I. and Mitsuhashi, S., 1977. Nature 266, 165–167.

    Google Scholar 

  33. Terakado, S., Ike, Y. and Mitsuhashi, S., 1979. in Epidemiology of Bacterial Resistance (Mitsuhashi, S., editor) pp 91–114, Kodansha; Academic Press, Tokyo and New York.

  34. Mitsuhashi, S., 1977. in R factor-Drug Resistance Plasmid (Mitsuhashi, S., editor) pp 37–48, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  35. Harada, K. and Mitsuhashi, S., 1977. in R factor-Drug Resistance Plasmid (Mitsuhashi, S., editor) pp 135–160, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  36. Harada, K., Kameda, M., Suzuki, M., Kakinuma, Y. and Mitsuhashi, S., 1961. Gunma J. Med. Sci. 10, 201–205.

    Google Scholar 

  37. Willets, N. S., 1977. in R factor-Drug Resistance Plasmid (Mitsuhashi, S., editor) pp 89–107, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  38. Curtiss III, R., 1977. ibid, pp 109–134.

  39. Rownd, R. H. and Womble, D. D., 1977. ibid, pp 161–194.

  40. Hashimoto, H. and Hirota, Y., 1966. J. Bacteriol. 91, 51–62.

    Google Scholar 

  41. Hashimoto, H. and Mitsuashi, S., 1970. Prog. Antimicrob. Anticancer Chemoth. 2, 545–551, Univ. of Tokyo Press, Tokyo.

    Google Scholar 

  42. Hashimoto, H. and Mitsuashi, S., 1966. J. Bacteriol. 92, 1351–1356.

    Google Scholar 

  43. Hashimoto, H., Tanaka, T. and Mitsuashi, S., 1973. Japan. J. Microbiol. 17, 331–337.

    Google Scholar 

  44. Ohtsubo, H. and Ohtsubo, E., 1977. in DNA Insertion Elements, Plasmids and Episomes (Bukhari, A. L, Shapire, J. A. and Adhya, S. L., editors) pp 49–63, Cold Spring Harbor Laboratory, New York.

  45. Katsumata, R., Hashimoto, H. and Mitsuhashi, S., 1979. Microbiol. Immunol. in press.

  46. Ike, Y., Hashimoto, H. and Mitsuhashi, S., 1977. in Plasmids (Mitsuhashi, S., Rosival, L. and Krcmery, V., editors) pp 277–283, Avicenum, Prague.

  47. Iyobe, S., Hashimoto, H. and Mitsuhashi, S., 1970. Japan. J. Microbiol. 14, 463–471.

    Google Scholar 

  48. Miki, T., Easton, A. M. and Rownd, R. H., 1978. Molec. Gen. Genet. 158, 217–224.

    Google Scholar 

  49. Mitsuhashi, S., Harada, K., Hashimoto, H., Kameda, M. and Suzuki, M., 1962. J. Bacteriol. 84, 9–16.

    Google Scholar 

  50. Watanabe, H., Ike, Y., Hashimoto, H. and Mitsuhashi, S., 1979. Microbial drug resistance (Mitsuhashi, S., editor) in press, Japan Scientific Societies Press, Tokyo.

  51. Hashimoto, H. and Rownd, R. H., 1975. J. Bacteriol. 123, 56–68.

    Google Scholar 

  52. Rownd, R. H., 1979. Microbial drug resistance. (Mitsuhashi, S., editor) in press, Japan Scientific Societies Press, Tokyo.

  53. Odakura, Y., Hashimoto, H. and Mitsuhashi, S., 1974. J. Bacteriol. 120, 1260–1267.

    Google Scholar 

  54. Yoshikawa, M., 1974. J. Bacteriol. 118, 1123–1131.

    Google Scholar 

  55. Harada, K., Kameda, M., Suzuki, M. and Mitsuhashi, S., 1963. J. Bacteriol. 86, 1332–1338.

    Google Scholar 

  56. Harada, K., Kameda, M., Suzuki, M. and Mitsuhashi, S., 1964. J. Bacteriol. 88, 1257–1265.

    Google Scholar 

  57. Kameda, M., Harada, K., Suzuki, M. and Mitsuhashi, S., 1965. J. Bacteriol. 90, 1174–1181.

    Google Scholar 

  58. Mitsuhashi, S., Kameda, M. Harada, K. and Suzuki, M., 1969. J. Bacteriol. 97, 1520–1521.

    Google Scholar 

  59. Anderson, E. S. and Natkin, E., 1972. Mol. Gen, Genet. 114, 261–265.

    Google Scholar 

  60. Mitsuhashi, S., 1971. in Ann. New York Acad. Sci. (Dulaney, E. L. and Laskin, A. L., editors) Vol. 182, pp 126–140, New York Acad. Sci., New York.

  61. Mitsuhashi, S., 1977. in Transferable Drug Resistance Factor R (Mitsuhashi, S., editor) pp 74–87, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  62. Mitsuhashi, S., Hashimoto, H., Iyobe, S. and Inoue, M., 1977. in DNA, Insertion Elements, Plasmids, and Episomes (Bukhari, A. L, Shapiro, J. A., and Adhya, S. L., editors) pp 139–146, Cold Spring Harbor Laboratory, New York.

  63. Kondo, E. and Mitsuashi, S., 1964. J. Bacteriol. 88, 1266–1276.

    Google Scholar 

  64. Kondo, E. and Mitsuhashi, S., 1966. J. Bacteriol. 91, 1787–1794.

    Google Scholar 

  65. Iyobe, S., Hashimoto, H. and Mitsuashi, S., 1970. Japan. J. Microbiol. 14, 463–471.

    Google Scholar 

  66. Inoue, M. and Mitsuhashi, S., 1976. Virology 72, 322–329.

    Google Scholar 

  67. Kameda, M., Suzuki, K. and Mitsuhashi, S., 1978. Microbiol. Immunol. 22, 173–180.

    Google Scholar 

  68. Sawai, Y., Hashimoto, H., Mitsuhashi, S. and Yamagishi, S., 1967. Japan. J. Microbiol. 11, 179–188.

    Google Scholar 

  69. Ooka, T., Hashimoto, H. and Mitsuhashi, S., 1970. Japan. J. Microbiol. 14, 123–128.

    Google Scholar 

  70. Odakura, Y., Tanaka, T., Hashimoto, H. and Mitsuhashi, S., 1972. Japan. J. Microbiol. 3, 315–324.

    Google Scholar 

  71. Odakura, Y., Hashimoto, H. and Mitsuhashi, S., 1974. J. Bacteriol. 120, 1260–1267.

    Google Scholar 

  72. Ike, Y., Hashimoto, H. and Mitsuhashi, S., 1976. in Plasmids-Medical and Theoritical Aspects. (Mitsuhashi, L., Rosival, L. and Krecmery, Vfi, editors) pp 277–283, Avicenum and Springer Verlag, Prague, Berlin, Heiderberg and New York.

  73. Ike, Y., Hashimoto, H. and Mitsuhashi, S., 1979. Microbiol. Immunol. in press.

  74. Yamamoto, T., Kato, R., Shimazu, A. and Yamagishi, A., 1979). J. Bacteriol. in press.

  75. Nordoström, K., Ingram, L. C., and Lundback, A., 1972. J. Bacteriol. 110, 562–569.

    Google Scholar 

  76. Morris, C. F., Hashimoto, H., Mickel, S. and Rownd, R., 1974. J. Bacteriol. 118, 855–866.

    Google Scholar 

  77. Iyobe, S., Kono, M., Ohara, K., Hashimoto, H. and Mitsuhashi, S., 1974. Antimicrob. Ag. Chemother. 5, 68–74.

    Google Scholar 

  78. Goebel, W. and Bonewald, R., 1975. J. Bacteriol. 123, 658–665.

    Google Scholar 

  79. Mickel, S. and Bauer, W., 1976. J. Bacteriol. 127, 644–655.

    Google Scholar 

  80. Taylor, D. P., Greenberg, J. and Rownd, R. H., 1977. J. Bacteriol. 132, 986–995.

    Google Scholar 

  81. Hashimoto, H. and Mitsuhashi, S., 1970. Proceeding of the 6th International Congress of Chemotheraphy “Progress in Antimicrobial and Anticancer Chemotheraphy” pp. 546–551, University of Tokyo Press, Tokyo.

    Google Scholar 

  82. Watanabe, H., Hashimoto, H. and Mitsuhashi, S., 1979. Genetical Research, in press.

  83. Watanabe, H., Hashimoto, H. and Mitsuashi, S., 1979. J. Bacteriol. in press.

  84. Rownd, R. and Michel, S., 1971. Nature (Lond) 234, 40–43.

    Google Scholar 

  85. Hashimoto, H. and Rownd, R., 1975. J. Bacteriol. 123, 56–68.

    Google Scholar 

  86. Tanaka, N., Cramer, J. H. and Rownd, R., 1976. J. Bacteriol. 127, 619–636.

    Google Scholar 

  87. Chandler, M., Allet, B., Gollary, E., Boy. dela. Tour, E. and Caro, E., 1977. Molec. Gen. Genet. 153, 289–295.

    Google Scholar 

  88. Datta, N., 1977. in Transferable Drug Resistance Factor R (Mitsuhashi, S., editor) pp 255–272, University of Tokyo Press, Tokyo.

  89. Mitshuashi, S., 1977. in Transferable Drug Resistance Factor R (Mitsuhashi, S., editor) pp 74–87, University of Tokyo Press, Tokyo.

  90. Bryan, L. E., Shahrabade, M. S., and Van Den Elzen, H. M., 1974. Antimicrob. Agents Chemother. 6, 191–199.

    Google Scholar 

  91. Iyobe, S., Sagai, H., Hasuda, K. and Mitsuhashi, S., 1977. in Plasmds-Medical and Theoretical Aspects (Mitsuhashi, S., Rosival, L. and Krcmery, V., editors) pp 95–100, Avicenum-Czechoslovak Medical Press, Prague; Springer Verlag, Berlin, Heiderberg, and New York.

  92. Jacoby, G. A., 1978. in Clinical Manifestations of Infestion and Current Therapy (Dogget, R. C., editor) Academic Press, New York, in press.

  93. Knotomichalou, P. and Papachristou, E., 1975. in Microbial Drug Resistance (Mitsuhashi, S. and Hashimoto, H., editors) pp 329–348, University of Tokyo Press, Tokyo.

  94. Holloway, B., 1969. Bacteriol. Rev. 33, 419–443.

    Google Scholar 

  95. Sagai, H., Krcmery, B., Hasuda, K., Iyobe, S., Knothe, H. and Mitsuhashi, S., 1975. Japan. J. Microbiol. 19, 427–432.

    Google Scholar 

  96. Inoue, M., Hashimoto, H. and Mitsuhashi, S., 1970. J. Antibiotics 23, 68–74.

    Google Scholar 

  97. Iyobe, S., Kono, M., Ohara, K., Hashimoto, H. and Mitsuhashi, S., 1974. Antimicrob. Agents Chemother. 5, 68–74.

    Google Scholar 

  98. Mitsuhashi, S., Yamagishi, S., Sawai, T. and Kawabe, H., 1977. in R-factor. Drug Resistance Plasmid (Mitsuhashi, S., editor) pp 195–254, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  99. Sawai, T., Takahashi, K., Yamagishi, S. and Mitsuhashi, S., 1970. J. Bacteriol. 104, 620–629.

    Google Scholar 

  100. Egawa, R., Sawai, T. and Mitsuhashi, S., 1967. Japan. J. Microbiol. 11, 173–178.

    Google Scholar 

  101. Yamagishi, S., Ohara, K., Sawai, T. and Mitsuhashi, S., 1969. J. Biochem. 66, 11–20.

    Google Scholar 

  102. Yaginuma, S., Terakado, N. and Mitsuhashi, S., 1975. Antimicrob. Agents Chemother. 8, 238–242.

    Google Scholar 

  103. Sawada, Y., Yaginuma, S., Tai, M., Iyobe, S. and Mitsuhashi, S., 1975. Antimicrob. Agents Chemother. 9, 55–60.

    Google Scholar 

  104. Sawai, T., Yamagishi, S. and Mitsuhashi, S., 1973. J. Bacteriol. 115, 1045–1054.

    Google Scholar 

  105. Kobayashi, F., Koshi, T., Eda, J., Yoshimura, Y. and Mitsuhashi, S., 1973. Antimicrob. Agents Chemother. 4, 1–5.

    Google Scholar 

  106. Lai, C., Weisblum, B., Fahnestock, S. and Nomura, M., 1973. J. Mol. Biol. 74, 67–72.

    Google Scholar 

  107. Kida, M., Igarashi, S., Okutani, T., Asako, T., Hiraga, K. and Mitsuhashi, S., 1974. Antimicrob. Agents Chemother. 5, 92–94.

    Google Scholar 

  108. Kida, M., Asako, T., Yoneda, M. and Mitsuhashi, S., 1975. in Microbial Drug Resistance (Mitsuhashi, S. and Hashimoto, H., editors) pp 441–448, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  109. Mitsuhashi, S., 1975. in Drug-inactivating Enzymes and Antibiotic Resistance. (Mitsuhashi, S., Rosival, L. and Krcmery, V., editors) pp 115–119, Avicenum Czechoslovak Medical Press; Springer-Verlag, Praque, Berlin, Heidelberg, and New York.

  110. Kawabe, H., Kondo, S., Umezawa, H. and Mitsuhashi, S., 1975. Antimicrob. Agents. Chemother. 7, 494–499.

    Google Scholar 

  111. Kawabe, H., Naito, N. and Mitsuhashi, S., 1975. Antimicrob. Agents Chemother. 7, 50–54.

    Google Scholar 

  112. Kobayashi, F., Yamaguchi, M., Eda, J., Hiramatsu, M. and Mitsuhashi, S., 1972. Gunma Rep. Med. Sci. 5, 291–301.

    Google Scholar 

  113. Suzuki, I., Takahashi, N., Shirato, S., Kawabe, H. and Mitsuhashi, S., 1975. in Microbial Drug Resistance (Mitsuhashi, S. and Hashimoto, H., editors) pp 463–473, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  114. Kawabe, H., Umezawa, H., Iyobe, S. and Mitsuhashi, S., 1976. in Plasmids-Medical and Theoretical Aspects. pp 365–371, Avicenum, Czechoslovak Medical Press; Springer Verlag, Prague, Berlin, Heidelberg, and New York.

  115. Mitsuhashi, S., 1975. in Drug Action and Drug Resistance in Bacteria. (2) Aminoglycoside Antibiotics (Mitsuhashi, S., editor) pp 179–210, University of Tokyo Press, Tokyo.

  116. Mitsuhashi, S. and Kawabe, H., 1979. The Aminoglycosides (A. Whelton and H. C. Neu, editors) Marcel Dekker Press, in press.

  117. Yamaguchi, M., Koshi, T., Kobayashi, F. and Mitsuhashi, S., 1972. Antimicrob. Agents Chemother. 2, 142–146.

    Google Scholar 

  118. Umezawa, H., 1975. in Drug Action and Drug Resistance in Bacteria. (2) Aminoglycoside Antibiotics (Mitsuhashi, S., editor) pp 211–248, University of Tokyo Press, Tokyo.

  119. Mitsuhashi, S., Kawabe, H., Fuse, A. and Iyobe, S., 1975. in Microbial Drug Resistance (Mitsuhashi, S. and Hashimoto, H., editors) pp 515–523, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

  120. Nagai, Y. and Mitsuhashi, S., 1972. J. Bacteriol. 109, 1–7.

    Google Scholar 

  121. Nagate, T., Inoue, M. and Mitsuhashi, S., 1978. Microbiol. Immunol. 22, 367–375.

    Google Scholar 

  122. Saito, T., Shimizu, M. and Mitsuhashi, S., 1971. in Drug Action and Drug Resistance in Bacteria. (1) Macrolide Antibiotics and Lincomycin. (Mitsuhashi, S., editor) pp 239–266, University of Tokyo Press, Tokyo.

  123. Saito, T. and Mitsuhashi, S., 1971. in Ann. New York Acad. Sci. (Dulaney, E. L. and Laskin, A. L., editors) 182, pp 267–278, New York Acad. Sci., New York.

  124. Matsubara, K. and Kaiser, A. D., 1968. in The bacteriophage Lambda (L. Frish, editor) pp 769–775, Cold Spring Harbor Laboratory, New York.

  125. Mitsuhashi, S., 1977. in R factor-Drug resistance plasmid (S. Mitsuhashi, editor) pp 279–305, University of Tokyo Press; University Park Press, Tokyo, Baltimore, and London.

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology, Laboratory of Drug Resistance in Bacteria, School of Medicine Gunma University, Maebashi, Japan

    Susumu Mitsuhashi

Authors
  1. Susumu Mitsuhashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mitsuhashi, S. Drug resistance plasmids. Mol Cell Biochem 26, 135–181 (1979). https://doi.org/10.1007/BF00423044

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00423044

Keywords

Search

Navigation