Abstract
Male rats were given increasing doses of morphine sulfate to cause addiction. Each injection was paired with a bell. After a number of pairings, the bell acquired conditional-stimulus property in that, like morphine, it prevented withdrawal hypothermia during 72 h of withholding morphine. In another group the withdrawal hypothermia was precipitated by withholding of morphine injections. The bell reversed that hypothermia.
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Roffman, M., Reddy, C. & Lal, H. Control of morphine-withdrawal hypothermia by conditional stimuli. Psychopharmacologia 29, 197–201 (1973). https://doi.org/10.1007/BF00414033
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DOI: https://doi.org/10.1007/BF00414033