Summary
Three new antibiotics, neoantimycin, neaureothin and ochramycin have been isolated from Streptoverticillium orinoci. The systematic position of the organism is discussed.
Neoantimycin is related to the antimycin antibiotics group; neoaureothin shows some similarity with aureothin. Ochramycin is an amphoteric compound containing in its molecule an octaene chromophore.
The first two antibiotics show a slight antifungal activity only. Ochramycin is active against gram +ve, but not against gram -ve bacteria; its activity against yeasts and fungi is very slight.
Toxicity data are reported; no therapeutical effectiveness has been observed in experimental infections in mice.
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Cassinelli, G., Grein, A., Orezzi, P. et al. New antibiotics produced by streptoverticillium orinoci, n. sp.. Archiv. Mikrobiol. 55, 358–368 (1967). https://doi.org/10.1007/BF00406442
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DOI: https://doi.org/10.1007/BF00406442