Summary
Two cloned rat astrocytoma cell lines, 36 B-10 and 40 A-2, maintained in vitro were treated with 1 mM dibutyryl cyclic AMP. This treatment induced arborization of cellular processes and rounding-up of cell bodies in both cell lines and was associated with increased microvillous development in 40 A-2. There were no detectable concomitant changes in either (a) the quantity or organization of microtubules or 80–100 nm microfilaments, or (b) the intensity of glial fibrillary acidic protein indirect immunofluorescence staining.
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Spence, A.M., Coates, P.W. Scanning and transmission electron microscopy of cloned rat astrocytoma cells treated with dibutyrul cyclic AMP in vitro. J Cancer Res Clin Oncol 100, 51–58 (1981). https://doi.org/10.1007/BF00405901
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DOI: https://doi.org/10.1007/BF00405901