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d-Penicillamin

Vom Baustein des Penicillins zum vielseitigen Pharmakon

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Abstract

d-Penicillamine is used against a variety of diseases. For many years it has been successful in treating Wilson's disease, cystinuria and heavy-metal poisonings. It also proved to be effective against rheumatoid arthritis, scleroderma, chronic active hepatitis, pulmonary fibrosis and multiple sclerosis. However, the use of d-penicillamine is still limited owing to the frequent occurrence of considerable, though generally reversible, side effects. This article deals with the history of d-penicillamine as well as the methods of its synthesis, its pharmacokinetics, effects and side effects. In addition, the significance of the stereo isomeric l-penicillamine is discussed.

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Authors and Affiliations

  1. Abteilung für Therapeutische Biochemie, Zentrum der Biologischen Chemie der Universität, D-6000, Frankfurt/M.

    Edgar Lodemann

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  1. Edgar Lodemann
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Prof. Dr. Adolf Wacker, der seit 25 Jahren mit der Problematik des Penicillamins vertraut ist und mich zur Beschäftigung mit dieser interessanten Verbindung angeregt hat, in Dankbarkeit zum 60. Geburtstag gewidmet.

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Lodemann, E. d-Penicillamin. Naturwissenschaften 66, 462–466 (1979). https://doi.org/10.1007/BF00399003

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  • DOI: https://doi.org/10.1007/BF00399003

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