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Spinal cord compression by eosinophilic granuloma of the cervical spine. Case report and review of the literature

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Abstract

Eosinophilic granuloma is an uncommon lesion, often self-limiting. A location in the spine is rare; until now, only 35 cases have been reported. MRI is the most effective diagnostic technique, although conventional X-ray can also be useful as a first approach.

Therapy consists of immobilization of the patients, surgery and chemotherapy as required by to the clinical findings of the lesion.

The role of radiotherapy is still controversial.

The authors describe the fourth case of eosinophilic granuloma of the cervical spine with neurological symptoms reported in literature.

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References

  1. Alley RM, MD Sussman: Rapidly progressive eosinophilic granuloma. Spine [Am] 17 (1992) 1517–1519

    Google Scholar 

  2. Baber WW, Numaguchi, JM Nadell, F Culicchia, AE Robinson: Eosinophilic granuloma of the cervical spine without vertebra plana. J Comp Tom 11 (1987) 346–349

    Google Scholar 

  3. Broadbent V, J Pritchard, E Davies: Spontaneous remission of multisystem histiocitosis X. Lancet 1 (1984) 253–254

    PubMed  Google Scholar 

  4. Burger PC, BW Scheithauer, FS Vogel: Surgical pathology of the nervous system and its coverings (3rd ed) Churchill Livingstone Inc, New York 1991

    Google Scholar 

  5. Capanna R, DS Springfield, R Biagini: Direct cortisone injection in eosinophilic granuloma of bone: a preliminary report on 11 patient. J Pediatr Orthoped 5 (1985) 539–542

    Google Scholar 

  6. Cohen M, J Zornoza, A Cangir et al: Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone. Radiology 136 (1980) 289–293

    Google Scholar 

  7. Davidson RI, J Shillito: Eosinophilic granuloma of the cervical spine in children. Pediatrics 45 (1970) 746–752

    Google Scholar 

  8. Dickinson D, SM Farhat: Eosinophilic granuloma of the cervical spine. Surg Neurol 35 (1991) 57–63

    Article  PubMed  Google Scholar 

  9. Fowles JV, WP Bobechko: Solitary eosinophilic granuloma in bone. J Bone Joint Surg 52B (1970) 238–243

    Google Scholar 

  10. Gangemi M, M Mayer, C Sainte-Rose, F Maiuri: Spinal cord compression by an eosinophilic granuloma. J Neurosurg Sci 29 (1985) 117–121

    Google Scholar 

  11. Green NE, WW Robertson, AW Kilroy: Eosinophilic granuloma of the spine with associated neural deficit. Report of three cases. J Bone Joint Surg 62 (1980) 1198–1202

    PubMed  Google Scholar 

  12. Green WT, S Farber: “Eosinophilic or solitary granuloma of bone”. J Bone Joint Surg 24 (1942) 499–526

    Google Scholar 

  13. Haggstrom JA, JC Brown, PW Marsh: Eosinophilic granuloma of the spine: MR demonstration. J Comput Assist Tomogr 12 (1988) 344–345

    PubMed  Google Scholar 

  14. Harmon DC: Chemotherapy. In: Sundaresan N, HH Schmidek, AL Schiller, DI Rosenthal (eds) Tumors of the spine. Diagnosis and clinical management. WB Saunders, Philadelphia 1990

    Google Scholar 

  15. Hatcher CH: Eosinophilic granuloma of bone. Arch Pathol 30 (1949) 69–76

    Google Scholar 

  16. Huvos AG: Bone Tumors Diagnosis, treatment and prognosis. (2nd ed) WB Saunders, Philadelphia 1991

    Google Scholar 

  17. Johnson S, T Klostermeier, A Weinstein: Case report 768. Skeletal Radiology 22 (1993) 63–65

    PubMed  Google Scholar 

  18. Lichtenstein L: Histiocitosis X. Integration of eosinophilic granuloma of bone, “Letterer-Siwe disease” and “Schuller-Christian disease” as related manifestation of a single nosologic entity. Arch Pathol 56 (1953) 84–102

    Google Scholar 

  19. Lichtenstein L, HI Jaffe: Eosinophilic granuloma of bone with report of a case. Am J Pathol 16 (1940) 595–604

    Google Scholar 

  20. Macnab GH: Discussion: eosinophilic granuloma, Letterer-Siwe disease, Hand-Schuller-Christian disease. Proc R Soc Med 48 (1955) 711–720

    Google Scholar 

  21. Mirra J: Bone tumors: diagnosis and treatment. JB Lippincot, Philadelphia 1980

    Google Scholar 

  22. Moscinski LC, BK Klein Schmidt-Demasters: Primary eosinophilic granuloma of the frontal lobe: diagnostic use of S-100 protein. Cancer 56 (1985) 284–288

    Google Scholar 

  23. Otani S, JC Ehrlich: Solitary granuloma of bone simulating primary neoplasm. Am J Pathol 16 (1940) 479–490

    Google Scholar 

  24. Rawlings CE, RH Wilkins: Solitary eosinophilic granuloma of the skull. Neurosurgery 15 (1984) 155–161

    Google Scholar 

  25. Ree HJ, ME Kadin: Peanut agglutinin: a useful marker for the detection of histiocytosis X and interdigitating reticulum cells. Cancer 57 (1986) 282–287

    Google Scholar 

  26. Reed VC, AU Bresolin, AB Lefeure: Granuloma eosinofilo da coluna cervical com manifestaçao neurologica, liquorica, e radiologica atipica. Arq Neuropsiquiatr 33 (1975) 168–177

    Google Scholar 

  27. Rosenblum ML: Comment to Rawlings CE and Wilkins RH. Neurosurgery 15 (1984) 161

    Google Scholar 

  28. Sanchez RL, J Llover, A Moreno, E Galito: Symptomatic eosinophilic granuloma of the spine. Orthopedics 7 (1984) 1721–1726

    Google Scholar 

  29. Sartoris DJ, BR Parker: Histiocitosis X: rate and pattern of resolution of osseus lesions. Radiology 17 (1984) 48–53

    Google Scholar 

  30. Seimon LP: Eosinophilic granuloma of spine. J Pediatr Orthop 1 (1981) 371–376

    Google Scholar 

  31. Sherk HH, JT Nicholson, JE Nixon: Vertebra plana and eosinophilic granuloma of the cervical spine of children. Spine 3 (1978) 116–121

    PubMed  Google Scholar 

  32. Slater JM, Swarm: Eosinophilic granuloma of bone. Med Pediatr Oncol 8 (1980) 151–164

    Google Scholar 

  33. Sweasey TA, RC Dauser: Eosinophilic granuloma of the cervicothoracic junction. J Neurosurg 71 (1989) 942–944

    Google Scholar 

  34. Tomita T: Special considerations in surgery of pediatric spine tomors. In: Sundaresan N, HH Schmidek, AL Schiller, DI Rosenthal (eds): Tumors of the spine. Diagnosis and clinical management. WB Saunders, Philadelphia 1990

    Google Scholar 

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Scarpinati, M., Artico, M. & Artizzu, S. Spinal cord compression by eosinophilic granuloma of the cervical spine. Case report and review of the literature. Neurosurg. Rev. 18, 209–212 (1995). https://doi.org/10.1007/BF00383729

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