Summary
Thiodiacetic acid and S-(carboxymethyl)cysteine are found in the urine of rats after a 48 h exposure to 1000 ppm vinyl chloride. The structure of both compounds could be clarified by GC-MS investigations. Chloroethylene oxide, chloroacetaldehyde and chloroacetic acid are assumed to be intermediates in vinyl chloride metabolism. Compounds which can be transformed to one of these alkylating agents in vivo should also lead to renal excretion of thiodiacetic acid and S-(carboxymethyl)cysteine.
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Müller, G., Norpoth, K. & Eckard, R. Identification of two urine metabolites of vinyl chloride by GC-MS-investigations. Int. Arch Occup Environ Heath 38, 69–75 (1976). https://doi.org/10.1007/BF00378322
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DOI: https://doi.org/10.1007/BF00378322