Summary
The unusual finding of an abnormal seasonal distribution of schizophrenic births, showing an excess of 10% in the winter or spring months and an equal deficit in the summer or autumn months, cannot be explained by artefacts. It has not yet been established whether the finding is specific to schizophrenia. We observed an excess of schizophrenic births of some 10% in March to May, significant at the 5% level, and a deficit of approximately the same size in June to August on the birth data of first-admission patients with the clinical diagnosis of schizophrenia. The data, obtained from the Mannheim Psychiatric Case Register, were compared with those of the Mannheim population and a control group matched by birth year and sex. The total population of mentally retarded children aged 7 to 16 years from the Mannheim population showed an excess of some 20% in April to June and an equal deficit in the last two quarters of the year, compared with the Mannheim population of the same birth years. The finding was not significant, but allowance must be made for the low case number of 415. We also compared 3409 first-admission patients with depressive syndromes (ICD 296 and 300.4) and 5615 first-admission patients with the diagnosis of “neurosis and personality disorders” (ICD 300–302, except 300.4, and 305–309) from the Mannheim Case Register with a control population and a parallel control group. Depressed males showed an excess of births in March to May, which was significant at the 1% level; the birth peak for females was smaller and not significant. The same findings were obtained for the category of neurosis and personality disorders, i.e. an excess of about 10% in March to May for males, significant at the 1% level, and a non-significant excess for females. Our findings are awaiting replication. Causal explanations will be discussed with great reservation. The procreational hypothesis, assuming those factors that lead to an equidirectional seasonal pattern of births with a slight deviation from the average of a year in the general population, to be reinforced in the disease categories mentioned, is regarded as the most simple and plausible explanation. It is based on the assumption that some of the parents of individuals suffering from schizophrenia, mental retardation or probably also some other mental disorders running from generation to generation, have a higher threshold in partner-seeking behaviour, which is overcome more easily in the summer months with the consequence of increased pregnancies.
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References
Boyd JH, Pulver AE, Stewart W (1986) Season of birth: Schizophrenia and pipolar disorder. Schizophr Bull 12:173–185
Bradbury TN, Miller GA (1985) Season of birth in schizophrenia: A review of evidence, methodology and etiology. Psychol Bull 98: 569–594
Buck C, Simpson H (1978) Season of birth among the sibs of schizophrenics. Br J Psychiatry 132:358–360
Crow T (1984) A re-evaluation of the viral hypothesis: Is psychosis the result of retroviral integration at a site close to the cerebral dominance gene? Br J Psychiatry 145:243–253
Dalen P (1968) Month of birth and schizophrenia. Acta Psychiatr Scand 203:55–60
Dalen P (1975) Season of birth: A study of schizophrenia and other mental disorders. North-Holland, Amsterdam
Dawson DF (1978) An explanation for the seasonality of births in schizophrenia. Am J Psychiatry 135:1434–1435
de Sauvage Nolting WJJ (1934) The relation between schizophrenic and related disorders and the month of birth. Ned T Geneesk 79: 528
de Sauvage Nolting WJJ (1951) The relation between the month of birth and schizophrenic and manic-depressive mental disorders. Ned T Geneesk 4:3855–3864
de Sauvage Nolting WJJ (1954) Vitamin C and the schizophrenic syndrome. Folio Psychiatry Neerl 57: 347–355
Dudgeon JA, Peckham CS, Marshall WC, Smithells RW, Sheppard S (1973) National congetial rubella surveillance programme. Health Trends 5:75–79
Ernst C, Angst J (1983) Birth order. Its influence on personality. Springer, Berlin, Heidelberg, New York
Gershon S, Shaw F (1961) Psychiatric sequelae of chronic exposure to organophospharous insecticides. Lancet 1:1371–1374
Hanshaw JB (1971) Congenital cytomegalovirus infection: a fifteen year perspective. J Infect Dis 123:555–561
Hare EH (1975a) Manic-depressive psychosis and season of birth. Acta Psychiat Scand 52:69–79
Hare EH (1975b) Season of birth in schizophrenia and neurosis. Am J Psychiatry 132:1168–1171
Hare EH (1976) The season of birth of siblings of psychiatric patients. Br J Psychiatry 119:49–54
Hare EH (1979) Schizophrenia as an infectious disease. Br J Psychiatry 35:468–470
Hare EH (1983) Epidemiological evidence for a viral factor in the aetiology of the functional psychoses. Adv Biol Psychiatry 12:52–75
Hare EH, Moran P (1981) A relation between seasonal temperature and the birth rate of schizophrenic patients. Acta Psychiatr Scand 63:396–405
Hare EH, Price JS (1968) Mental disorder and season of birth: Comparison of psychoses with neuroses. Br J Psychiatry 115:533–540
Hare EH, Price JS, Slater E (1974) Mental disorder and season of birth: A national sample compared with the general population. Br J Psychiatry 124:81–86
Huntington E (1938) Season of birth: Its relation to human abilities. Wiley, New York
Kellett J (1978) Seasonality in schizophrenia. Lancet 1:664
Kendell RE, Kemp IW (1985) Winter born v. summer born schizophrenics. Paper presented at the World Psychiatric Association Section Symposium “The future of psychiatric epidemiology”, 23–26 September 1985, Edinburgh
Kinney DK, Jacobsen B (1978) Environmental factors in schizophrenia: New adoption study evidence. In: Wynne LC, Cromwell RL, Matthysse S (eds) The nature of schizophrenia: New approaches to research and treatment. Wiley, New York, pp 38–51
Klug J (1983) Psychiatrische Diagnosen: Einflußfaktoren auf die Stabilität im zeitlichen Verlauf. Beltz, Weinheim, Basel
Krauthammer C, Klerman GL (1979) The epidemiology of mania. In: Shopsin B (ed) Manic illness. Raven Press, New York, pp 11–28
Lewis M, Griffin T (1981) An explanation for the season of birth effect in schizophrenia and certain other diseases. Psychol Bull 89: 589–596
Machon R, Sarnoff A, Mednick S, Schulsinger F (1983) The interaction of seasonality, place of birth, genetic risk and subsequent schizophrenia in a high risk sample. Br J Psychiatry 143:383–388
McNeil T, Kaij L, Dzierzykray-Rogalska M (1976) Season of birth among siblings of schizophrenics. Acta Psychiatr Scand 54:267–274
Ödegard O (1974) Season of birth in the general population and in patients with mental disorder in Norway. Br J Psychiatry 125:397–405
Ödegard O (1977) Season of birth in the population of Norway, with particular reference to the September birth maximum. Br J Psychiatry 131:339–344
O'Hare A, Walsh D, Torrey F (1980) Seasonality of schizophrenic births in Ireland. Br J Psychiatry 137:74–77
Parker G, Balza B (1977) Season of birth and schizophrenia — an equatorial study. Acta Psychiatr Scand 56:143–146
Parker G, Neilson M (1976) Mental disorder and season of birth — a southern hemisphere study. Br J Psychiatry 129:355–361
Peckham CS (1978) Congenital rubella surveillance. J R Coll - Physicans Lond 12:250–255
Pulver AE, Stewart W, Carpenter WT, Childs B (1983) Risk factors in schizophrenia: Season of birth in Maryland, USA. Br J Psychiatry 143:389–396
Shensky T, Shur E (1982) Season of birth of schizophrenics: Cyclic trends and their analysis. Br J Psychiatry 141:316–317
Shimura M, Miura T (1980) Season of birth in mental disorders in Tokyo, Japan, by year of birth, year of admission, and age at admission. Acta Psychiatr Scand 61:21–28
Shimura M, Nakamura I, Miura T (1977) Season of birth of schizophrenia in Tokyo, Japan. Acta Psychiatr Scand 55:225–232
Shur E (1982) Season of birth in high and low genetic risk schizophrenics. Br J Psychiatry 140:410–415
Shur E, Hare E (1983) Age-prevalence and the season of birth effect in schizophrenia: A response to Lewis and Griffin. Psychol Bull 93:373–377
Taylor GR, Crow TJ, Ferrier IN, Johnstone EC, Parry RP, Tyrrell DAJ (1982) Virus-like agent in CSF in schizophrenia and some neurological disorders. Lancet 11:1166–1167
Templer DI (1982) Comment on the Lewis and Griffin explanation for season of birth effect in schizophrenia. J Orthomolecular Psychiatry 11:219–221
Templer D, Austin R (1980) Decreasing seasonality of schizophrenic births. Arch Gen Psychiatry 37:959–960
Templer D, Veleber D (1982) Seasonality of schizophrenic births: Harmful effects or genetic morphism? Br J Psychiatry 140:323–324
Torrey EF, Torrey BB (1979) A shifting seasonality of schizophrenic births. Br J Psychiatry 134:183–186
Torrey EF, Torrey BB, Peterson MR (1977) Seasonality of schizophrenic births in the United States. Arch Gen Psychiatry 34: 1065–1070
Tramer M (1929) Über die biologische Bedeutung des Geburtsmonates, insbesondere fur die Psychoseerkrankung. Schweiz Arch Neurol Psychiatr 24:17–24
Tyrrell DAJ, Crow TJ, Parry RP, Johnstone EC, Ferrier IN (1979) Possible virus in schizophrenia and some neurological disorders. Lancet I:839–841
Videbech T, Weeke A, Dupont A (1974) Endogenous psychoses and season of birth. Acta Psychiatr Scand 50:202–218
Watson CG (1985) Birth seasonality and schizophrenia. In reply. Arch Gen Psychiatry 42:107–108
Watson CG, Kucala T, Angulski G, Brunn C (1982) Season of birth and schizophrenia: a response to the Lewis and Griffin critique. J Abnorm Psychol 91:120–125
Watson CG, Kucala T, Tilleskjor C, Jacobs L (1984) Schizophrenic birth seasonality in relation to the incidence of infectious diseases and temperature extremes. Arch Gen Psychiatry 41:85–90
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Hafner, H., Haas, S., Pfeifer-Kurda, M. et al. Abnormal seasonality of schizophrenic births A specific finding?. Eur Arch Psychiatr Neurol Sci 236, 333–342 (1987). https://doi.org/10.1007/BF00377422
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DOI: https://doi.org/10.1007/BF00377422