Abstract
Spontaneously beating isolated preparations of cat and rabbit sinus were subjected to stretch.
Stretching the preparations increased their frequency. The effect was stronger, when stretch was applied concentrically than when it was applied linearly. Preparations from young animals showed a greater frequency response to stretch than did preparations from adult animals. During stretching the maximum diastolic potential decreased in preparations of the sinus as well as of spontaneously beating Purkinje fibers.
Changes in temperature, pH and ionic composition of the bath did not modify the frequency response of the stretched preparations. When the frequency of the preparations was lowered by hypoxia or application of acetylcholine the percentage increase of frequency during stretch was significantly higher than under normal conditions. The implications of the results concerning the Bainbridge reflex are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Aviado, D. M., T. H. Li, W. Kalow, C. F. Schmidt, G. L. Turnbull, G. W. Peskin, M. E. Hess, and A. J. Weiss: Respiratory and circulatory reflexes from the perfused heart and pulmonary circulation of the dog. Amer. J. Physiol. 165, 261–277 (1951).
Bainbridge, F. A.: The influence of venous filling upon the rate of the heart. J. Physiol. (Lond.) 50, 65–84 (1915).
Balling, J. R., and L. N. Katz: Observation on the localisation of the receptor area of the Bainbridge reflex. Amer. J. Physiol. 135, 202–213 (1941).
Barer, G. R., and S. R. Kottegoda: Changes in heart rate and blood pressure of the cat in response to increased pressure in the right side of the heart. J. Physiol. (Lond.) 143, 1–10 (1958).
Blinks, J. R.: Positive chronotropic effect of increasing right atrial pressure in the isolated mammilian heart. Amer. J. Physiol. 186, 299–303 (1956).
Bülbring, E.: Correlation between membrane potential, spike discharge and tension in smooth muscle. J. Physiol. (Lond.) 128, 200–221 (1955).
Coleridge, J. C. G., and R. J. Linder: Effect of intravenous infusion upon heart rate. J. Physiol. (Lond.) 128, 310–319 (1955).
Deck, K. A.: Änderungen des Ruhepotentials und der Kabeleigenschaften von Purkinje-Fäden bei der Dehnung. Pflügers Arch. ges. Physiol. 280, 131–140 (1964).
Dudel, J., u. W. Trautwein: Das Aktionspotential und Mechanogramm des Herzmuskels unter dem Einfluß der Dehnung. Cardiologia (Basel) 25, 344–362 (1950).
Gillepsie, J. S.: Spontaneous mechanical and electrical activity of stretched and unstretched intestinal smooth muscle cells and their response to sympathetic nerve stimulation. J. Physiol. (Lond.) 162, 54–75 (1962).
Graff, A. G. de, and J. Sands: Are reflexes from the large veins or auricle of importance in the regulation of the circulation? Amer. J. Physiol. 74, 400–415 (1925).
Hecht, H. H., and O. F. Hutter: The action of pH on cardiac muscle. Simposio internationale di Elettrofisiologia del Cuore. Milano (11–13 ottobre 1963) (im Druck). Oxford: Pergamon Press.
Jarisch, A., and Y. Zottermann: Depressor reflexes from the heart. Acta physiol. scand. 16, 31–51 (1948).
Koepchen, H. P., u. K. Thurau: Über die Rolle des Vagus bei der durch venöse Infusion erzeugten Herzfrequenzsteigerung. Pflügers Arch. ges. Physiol. 264, 573–584 (1957).
Ling, G., and R. W. Gerard: The influence of stretch on the membrane potential of the striated muscle fiber. J. cell. comp. Physiol. 34, 397–412 (1962).
Ludwig, J. M., u. B. Luchsinger: Zur Physiologie des Herzens. Pflügers Arch. ges. Physiol. 25, 211–250 (1881).
Okada, H., K. Okamoto, and I. Nisida: The activity of the cardioregulatory and abdominal sympathetic nerves of the cat in the Bainbridge reflex. Jap. J. Physiol. 11, 520–529 (1961).
Pathak, C. L.: Alternative mechanism of cardiac acceleration in Bainbridge's infusion experiments. Amer. J. Physiol. 197, 441–444 (1959).
Reiter, M., u. J. Noé: Die Bedeutung von Calcium, Magnesium, Kalium und Natrium für die rhythmische Erregungsbildung im Sinusknoten des Warmblüterherzens. Pflügers Arch. ges. Physiol. 254, 366–374 (1959).
Rothschuh, K. E.: Über Dehnungspotentiale am M. sartorius und am Herzmuskel des Frosches. Pflügers Arch. ges. Physiol. 254, 171–192 (1951).
Sassa, K., and H. Miyazaki: The influence of the venous pressure on the heart rate. J. Physiol. (Lond.) 54, 203–212 (1920)
Schmier, J.: In: Probleme der Coronarblutung. Berlin, Göttingen, Heidelberg: Springer 1958.
Schütz, E.: Physiologie des Herzens, S. 164. Berlin, Göttingen, Heidelberg: Springer 1958.
Sewall, H., and F. Donaldson: On the influence of variations of intracardiac pressure upon the inhibitory action of the vagus nerve. J. Physiol. (Lond.) 3, 357–368 (1882).
Tiitso, M.: Chronotrope Wirkungen der Spannungsänderung des rechten Vorhofs. Pflügers Arch. ges. Physiol. 238, 738–748 (1937).
—M. Tiitso. Über die Bedingungen des Zustandekommens des chronotropen Effektes der Dehnung des rechten Vorhofs beim Hund. Pflügers Arch. ges. Physiol. 242, 685–690 (1939).
Trautwein, W.: In Spang: Rhythmusstörungen des Herzens, S. 57. Stuttgart: G. Thieme 1957.
—W. Trautwein, J. Dudel: Zum Mechanismus der Membranwirkung des Acetylcholins an der Herzmuskelfaser. Pflügers Arch. ges. Physiol. 266, 653–664 (1958).
Woodbury, W. W., and A. J. Brady: Intracellular recording from moving tissues with a flexible mounted ultramicroelectrode. Science 23, 100–101 (1956).
Author information
Authors and Affiliations
Additional information
Herrn Professor Dr. Max Schneider zur Vollendung des 60. Lebensjahres gewidmet.
Mit 3 Textabbildungen
Mit Unterstützung der Deutschen Forschungsgemeinschaft.
Rights and permissions
About this article
Cite this article
Deck, K.A. Dehnungseffekte am spontanschlagenden, isolierten Sinusknoten. Pflügers Archiv 280, 120–130 (1964). https://doi.org/10.1007/BF00363751
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00363751