Zusammenfassung
Die im Herzmuskel vorhandene Konzentration an energiereichen Phosphaten wurde am Herzlungen-Präparat von Ratten unter verschiedenen Herzleistungs- und Herzarbeitsbedingungen bestimmt.
Durch zweckmäßige Änderungen des mittleren arteriellen Blutdrucks und des Herzminutenvolumens wurden den Präparaten fünf verschiedene Leistungsniveaus auferlegt (24,9, 31,3, 36,5, 49,7 und 65,9 g meter/min).
Es wurden drei verschiedene Werte der Herzarbeit (das heißt 0,182, 0,942, 1,884 kgmeter) (bei unverändertem Leistungsgrad) erhalten, indem man die Präparate jeweils 5, 30, 60 min arbeiten ließ.
Die Unterbrechung der mechanischen Leistung der Präparate und die Herausnahme des Herzens zur chemischen Analyse erfolgten immer in Abwesenheit von Herzdekompensationszeichen.
Die statistische Analyse der Ergebnisse zeigte, daß es im Rahmen der physiologischen Herzbelastung unmöglich ist, eine Korrelation zwischen Herzleistungs- oder Herzarbeitsgrad und Konzentration von energiereichen Phosphaten im Myokard nachzuweisen.
Wenn keine Herzdekompensationszeichen trotz der bedeutenden hämodynamischen Herzbelastung vorhanden sind, wird die Spaltung der energiereichen Phosphate durch die Resynthesevorgänge völlig ausgeglichen.
Summary
The high-energy phosphates content in myocardial tissue has been estimated in the rat heart-lung preparation under various levels of cardiac load and after delivering of various amounts of work.
Five cardiac loads (i.e. 24.9, 31.3, 36.5, 49.7, and 65.9 gmeter/min) were imposed to the preparations by suitably varying the mean arterial blood pressure and the cardiac output.
Three different amounts of cardiac work (i. e. 0.182, 0.942, 1.884 kgmeter) were obtained (at the same load) by allowing the preparation to work for 5, 30 and 60 min respectively.
The preparations were stopped and the heart removed for the chemical analysis in the absence of signs of failure.
The statistical analysis of the results showed that, within the physiological range of mean arterial blood pressure and cardiac output, no correlation between the load imposed or the work performed and the content of high-energy phosphate in the heart can be observed.
As far as no signs of cardiac failure are present, the high-energy phosphates breakdown is perfectly balanced by resynthesis processes, even when a considerable haemodynamic load is imposed to the heart.
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Minelli, R., Casella, C. Influence of load and work on the high energy phosphates content in the myocardium (rat heart-lung preparation). Pflügers Archiv 295, 119–126 (1967). https://doi.org/10.1007/BF00362743
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DOI: https://doi.org/10.1007/BF00362743