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Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules

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Abstract

An anti-I-Ek alloantiserum was shown to react with purified human Ia preparation. All Ia preparations tested were actively bound irrespective of their HLA-DR phenotypes. However, from a quantitative point of view, DR7 molecules were significantly less reactive. No reaction was observed with isolated Ia subunits. Only molecules carrying DR determinants, but not those carrying either DC1 or BR4X7 determinants, were bound.

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Authors and Affiliations

  1. Laboratory of Cell Biology, Via Romagnosi 18 A, 00196, Roma, Italy

    Roberto Tosi & Rosa Sorrentino

  2. Department of Immunology Research, Roswell Park Memorial Institute, 14263, Buffalo, New York

    Nobuyuki Tanigaki

  3. Gruppo di Microbiologia e Patologia Generale, Universitá di Roma, Italy

    Rosa Sorrentino

  4. Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinic Immunology, University of Amsterdam, Amsterdam, The Netherlands

    Peter van Mourik & Pavol Ivanyi

Authors
  1. Roberto Tosi
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  2. Nobuyuki Tanigaki
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  3. Rosa Sorrentino
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  4. Peter van Mourik
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  5. Pavol Ivanyi
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Tosi, R., Tanigaki, N., Sorrentino, R. et al. Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules. Immunogenetics 16, 187–199 (1982). https://doi.org/10.1007/BF00343308

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  • DOI: https://doi.org/10.1007/BF00343308

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