Skip to main content
Log in

Genetical aspects of [URE3], a non-mitochondrial, cytoplasmically inherited mutation in yeast

  • Published:
Molecular and General Genetics MGG Aims and scope Submit manuscript

Summary

[URE3], a non-mitochondrial non-mendelian mutation which modifies drastically yeast nitrogen metabolism has been genetically studied. Cytoduction experiments show definitely that the inheritance of the determinant is not linked to the nucleus. The maintenance of the [URE3] determinant seems controlled by the product of a conventional nuclear gene (ure2) which is itself involved in nitrogen metabolism. The (ure2) mutation alone gives the same phenotype as [URE3] but it is impossible to obtain a stable recombinant containing simultaneously the (ure2) mutation and the [URE3] determinant. Application of the Newcombe respreading experiment demonstrates that the [URE3] mutational event occurs before the selection procedure and is therefore not strictly adaptative. Nevertheless, the nature of the selection medium changes considerably the frequency of the [URE3] mutants recovered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Birky, C. W.: On the origin of mitochondrial mutants: evidence for intracellular selection of mitochondria in the origin of AntR cells in yeast. Genetics 74, 421–432 (1973)

    Google Scholar 

  • Brinck, R. A.: Paramutation. Ann. Rev. Genet. 7 129–152 (1973)

    Google Scholar 

  • Drillien, R., Aigle, M., Lacroute, F.: Yeast mutants pleiotropocally impaired in the regulation of the two glutamate dehydrogenases. Biochem. biophys. Res. Commun. 53, 2, 367–372 (1973)

    Google Scholar 

  • Drillien, R., Lacroute, F.: Ureidosuccinic acid uptake in yeast and some aspects of its regulation. J. Bact. 109, 1, 203–208 (1971)

    Google Scholar 

  • Lacroute, F.: Non-mendelian mutation allowing ureidosuccinic acid uptake in yeast. J. Bact. 106, 2, 519–522 (1971)

    Google Scholar 

  • McLaughlin, C. S., Warner, J. R., Edmonds, M., Nakazato, H., Vaugman, M. H.: Polyadenylic acid sequences in yeast messenger ribonucleic acid. J. biol. Chem. 248, 4, 1466–1471 (1973)

    Google Scholar 

  • Petersen, N. S., McLaughlin, C. S.: Monocistronic Messenger RNA in yeast. J. molec. Biol. 81, 33–45 (1973)

    Google Scholar 

  • Wright, F., Lederberg, J.: Extranuclear transmission in yeast heterokayons. Proc. nat. Acad. Sci. (Wash.) 43, 919–923 (1957)

    Google Scholar 

  • Zakharov, Y. A., Yurthenko, L. V., Yarovoy, B. P.: Cytoduction: autonomous transfer of cytoplasmic hereditary factors in the course of mating in the yeast Saccharomyces cerevisiae. Genetika 5, 136–141 (1969)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Communicated by F. Kaudewitz

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aigle, M., Lacroute, F. Genetical aspects of [URE3], a non-mitochondrial, cytoplasmically inherited mutation in yeast. Molec. gen. Genet. 136, 327–335 (1975). https://doi.org/10.1007/BF00341717

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00341717

Keywords

Navigation