Summary
The RpII215 region of the X chromosome of Drosophila melanogaster was investigated to identify genetic functions and correlate these with the known molecular organization of the region. Five genetic loci were identified in a subregion that is reported to transcribe nine or more messages. One locus is nod, which causes meiotic abnormalities, and three other loci are recessive lethal mutations whose developmental lesions are unknown. The fifth and most mutable of the loci is RpII215, which encodes the 215,000 dalton subunit of RNA polymerase II. Mutant effects of RpII215 alleles include: temperature-dependent (heat and cold) survival, altered sensitivity to α-amanitin, male sterility, maternal effects and epistatic enhancement of mutant effects of other loci.
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Communicated by M.M. Green
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Voelker, R.A., Wisely, G.B., Huang, SM. et al. Genetic and molecular variation in the RpII215 region of Drosophila melanogaster . Molec Gen Genet 201, 437–445 (1985). https://doi.org/10.1007/BF00331336
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DOI: https://doi.org/10.1007/BF00331336