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A comparative study of the adrenergic nerves to the anterior eye segment of some primates

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Summary

The distribution of adrenergic terminals to the anterior eye segment of humans, Cynomolgue monkeys, squirrel monkeys, owl monkeys, Cebus monkeys, vervets, tamarins, and baboons has been investigated. The cornea is normally devoid of adrenergic terminals, except in a plexus near the limbus. The trabecular meshwork contains varying numbers of adrenergic terminals: usually none in Cynomolgus monkeys, patas monkeys, vervets, and humans, although fibres have very rarely been observed in Cynomolgus monkeys, vervets, and humans; a few in owl monkeys, squirrel monkeys, and tamarins; and moderate numbers in Cebus monkeys and baboons. From the evidence, however, it seems premature to presume an adrenergic innervation of the trabecular mechanism regulating the outflow resistance. The dilatator pupillae is regularly supplied with numerous adrenergic terminals and in the iris stroma there is probably an adrenergic innervation of the melanophores. The sphincter pupillae regularly contains adrenergic terminals with notable species differences; most fibres occur in baboons and fewest in humans, with the remaining species forming a middle class. The ciliary processes in all species contain a moderate number of adrenergic terminals, presumably primarily associated with the epithelium. Intraepithelial adrenergic terminals have been observed on the pars plana of the ciliary body of humans, Cebus monkeys, vervets, baboons, and patas monkeys. The ciliary muscle of baboons and Cynomolgus monkeys contains numerous adrenergic terminals. Moderate numbers occur in Cebus monkeys and vervets, and still less in (in falling order) tamarins, squirrel monkeys, humans, and patas monkeys.

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References

  • Alphen, G. W. H. M. van, Kern, R., Robinette, S. L.: Adrenergic receptors of the intraocular muscles. Arch. Ophthal. 74, 253–259 (1965).

    Google Scholar 

  • Bárány, E. H.: Topical epinephrine affects on true outflow resistance and pseudofacility in vervet monkeys studied by a new anterior chamber perfusion technique. Invest. Ophthal. 7, 88–104 (1968).

    Google Scholar 

  • Bill, A.: Conventional and uveo-scleral drainage of aqueous humour in the cynomolgus monkey (Macaca irus) at normal and high intraocular pressures. Exp. Eye Res. 5, 45–54 (1966).

    Google Scholar 

  • —: Effects of atropine and pilocarpine on aqueous humour dynamics in Cynomolgus monkeys (Macaca irus), Exp. Eye Res. 6, 120–125 (1967).

    Google Scholar 

  • —: Early effects of epinephrine on aqueous humor dynamics in vervet monkeys (Cercopithectus ethiops). Exp. Eye Res. 8, 35–43 (1969).

    Google Scholar 

  • Björklund, A., Falck, B.: An improvement of the histochemical fluorescence method for monoamines. Observations on varying extractability of fluorophores in different nerve fibres. J. Histochem. Cytochem. 16, 717–720 (1968).

    Google Scholar 

  • —, Owman, Ch.: Fluorescence microscopic and microspectrofluorometric techniques for the cellular localization and characterization of biogenic amines. In: Methods of investigative and diagnostic endocrinology, ed. I. Kopin. The Hague: North Holland Publ. Corp. 1971.

    Google Scholar 

  • Corrodi, H., Jonsson, G.: The formaldehyde fluorescence method for the histochemical demonstration of biogenic monoamines. A review on the methodology. J. Histochem. Cytochem. 15, 65–78 (1967).

    Google Scholar 

  • Ehinger, B.: Adrenergic nerves to the eye and its adnexa in rabbit and guinea-pig. Acta Univ. Lund., Sectio II 20, 1–23 (1964).

    Google Scholar 

  • —: Noradrenaline and cholinesterases in concomitant nerve fibres in the rat iris. Life Sci. 4, 2097–2100 (1965).

    Google Scholar 

  • —: Adrenergic nerves to the eye and to related structures in man and in the Cynomolgus monkey. Invest. Ophthal. 5, 42–52 (1966a).

    Google Scholar 

  • —: Distribution of adrenergic nerves in the eye and some related structures in the cat. Acta physiol. scand. 66, 123–128 (1966b).

    Google Scholar 

  • —: Connections between adrenergic nerves and other tissue components in the eye. Acta physiol. scand. 67, 57–64 (1966c).

    Google Scholar 

  • —: Localization of ocular adrenergic nerves and barrier mechanisms in some mammals. Acta ophthal. (Kbh.) 44, 814–822 (1966d).

    Google Scholar 

  • —: Ocular and orbital vegetative nerves. Acta physiol. scand. 67, Suppl. 268, 1–35 (1966e).

    Google Scholar 

  • —: Double innervation of the feline iris dilator. Arch. Ophthal. 77, 541–545 (1967a).

    Google Scholar 

  • —: Adrenergic nerves in the avian eye and ciliary ganglion. Z. Zellforsch. 82, 577–588 (1967b).

    Google Scholar 

  • —, Falck, B.: Concomitant adrenergic and parasympathetic fibres in the rat iris. Acta physiol. scand. 67, 201–207 (1966).

    Google Scholar 

  • —: Adrenergic retinal neurons of some new world monkeys. Z. Zellforsch. 100, 364–375 (1969).

    Google Scholar 

  • —: Innervation of iridic melanophores. Z. Zellforsch. 105, 538–542 (1970).

    Google Scholar 

  • Ehinger, B., Falck, B.: Uptake of some monoamines into neurons of the ciliary ganglion. Acta physiol. scand. 78, 132–141 (1970).

    Google Scholar 

  • —, Sporrong, B.: Adrenergic fibres to the heart and to peripheral vessels. Bibl. anat. (Basel) 8, 35–45 (1967).

    Google Scholar 

  • —: Possible axo-axonal synapses between peripheral adrenergic and cholinergic nerve terminals. Z. Zellforsch. 107, 508–521 (1970).

    Google Scholar 

  • - Sjöberg, N-O.: Development of the ocular adrenergic nerve supply in man and guinea-pig. Z. Zellforsch. in press (1971).

  • —, Sporrong, B.: Adrenergic and cholinergic axons in the mouse iris. Experientia (Basel) 22, 218 (1966).

    Google Scholar 

  • —, Stenevi, U.: Simultaneous demonstration of adrenergic and non-adrenergic nerve fibres. Histochemie 13, 105–110 (1968).

    Google Scholar 

  • Eränkö, O.: The practical histochemical demonstration of catecholamines by formaldehyde induced fluorescence. J. roy. micr. Soc. 87, 259–276 (1967).

    Google Scholar 

  • —, Räisänen, L.: Fibres containing both noradrenaline and acetylcholinesterase in the nerve net of the rat iris. Acta physiol. scand. 63, 505–506 (1965).

    Google Scholar 

  • Falck, B.: Observations on the possibilities of the cellular localization of monoamines by a fluorescence method. Acta physiol. scand. 56, Suppl. 197, 1–25 (1962).

    Google Scholar 

  • Geltzer, A. I.: Autonomic innervation to the cat iris. An electron microscopic study. Arch. Ophthal. 81, 70–83 (1969).

    Google Scholar 

  • Hökfelt, T., Nilsson, O.: The relationship between nerves and smooth muscle cells in the rat iris. Z. Zellforsch. 66, 848–853 (1965).

    Google Scholar 

  • Krapp, J.: Elektronenmikroskopische Untersuchungen über die Innervation von Iris und Corpus ciliare der Hauskatze unter besonderer Berücksichtigung der Muskulatur. Z. mikr. anat. Forsch. 68, 418–447 (1962).

    Google Scholar 

  • Laties, A., Jacobowitz, D.: A histochemical study of the adrenergic and cholinergic innervation of the anterior segment of the rabbit eye. Invest. Ophthal. 3, 592–600 (1964).

    Google Scholar 

  • —: A comparative study of the autonomic innervation of the eye in monkey, cat and rabbit. Anat. Rec. 156, 383–396 (1966).

    Google Scholar 

  • Lukáš, Z., Čech, S.: Histochemical localization of monoamine oxidase in the anterior segment of the eye and the adrenergic innervation of its tissues. Acta histochem. (Jena) 21, 154–164 (1965).

    Google Scholar 

  • —: Adrenergic nerve fibres and their relation to monoamine oxidase distribution in ocular tissues. Acta histochem. (Jena) 25, 133–140 (1966).

    Google Scholar 

  • —, Mazanec, K.: Innervation of the ciliary epithelium. Z. Mikr. Anat. Forsch. 76, 530–537 (1967).

    Google Scholar 

  • Malmfors, T.: Direct demonstration of the systems of terminals belonging to an individual adrenergic neuron and their distribution in rat iris. Acta physiol. scand. 64, 377–384 (1965).

    Google Scholar 

  • —: The adrenergic innervation of the eye as demonstrated by fluorescence microscopy. Acta physiol. scand. 65, 259–267 (1965).

    Google Scholar 

  • —: Histochemical studies on the adrenergic innervation of the nictitating membrane. Histochemie 13, 203–206 (1968).

    Google Scholar 

  • Nilsson, O.: The relationship between nerves and smooth muscle cells in the rat iris. I. The dilatator muscle. Z. Zellforsch. 64, 166–171 (1964).

    Google Scholar 

  • Nishida, S., Sears, M.: Fine structural innervation of the dilator muscle of the iris of the albino guinea pig studied with permanganate fixation. Exp. Eye Res. 8, 292–296 (1969).

    Google Scholar 

  • Norberg, K-A.: Transmitter histochemistry of the sympathetic adrenergic nervous system. Brain Res. 5, 125–170 (1967).

    Google Scholar 

  • Ochi, J., Konishi, M., Yoshikawa, H., Sano, Y.: Fluorescence and electron microscopic evidence for the dual innervation of the iris sphincter muscle of the rabbit. Z. Zellforsch. 91, 93–95 (1968).

    Google Scholar 

  • Posner, J.: The inhibitory innervation of the bovine iris sphincter. Brit. J. Pharmacol. 37, 515P (1969).

    Google Scholar 

  • Richardson, K. C.: The fine structure of the albino rabbit iris with special reference to the identification of adrenergic and cholinergic nerves and nerve endings in its intrinsic muscles. Amer. J. Anat. 114, 173–205 (1964).

    Google Scholar 

  • Richardson, K. C.: The fine structure of autonomic nerves after vital staining with methylene blue. Anat. Rec. 164, 359–377 (1969).

    Google Scholar 

  • Rohen, J.: Das Auge und seine Hilfsorgane. In: Handbuch der Mikroskopischen Anatomie des Menschen, W. Bargmann, Ed., vol. II/4. Berlin-Göttingen-Heidelberg-New York: Springer 1964.

    Google Scholar 

  • Ruskell, G. L.: The fine structure of nerve terminations in the lacrimal glands of monkeys. J. Anat. (Lond.) 103, 65–76 (1968).

    Google Scholar 

  • —: Changes in nerve terminals and acini of the lacrimal gland and changes in secretion induced by autonomic denervation. Z. Zellforsch. 94, 261–281 (1969).

    Google Scholar 

  • Schaeppi, V., Koella, W. P.: Adrenergic innervation of cat iris sphincter. Amer. J. Physiol. 207, 273–279 (1964).

    Google Scholar 

  • —, Rubin, R., Koella, W. P.: Electrical stimulation of the isolated cat iris. Amer. J. Physiol. 210, 1165–1169 (1966).

    Google Scholar 

  • Scott, B. L., Pease, D. C.: Electron microscopy of the salivary and lacrimal glands of the rat. Amer. J. Anat. 104, 115–161 (1959).

    Google Scholar 

  • Staflova, J.: Adrenergic innervation of the iris, ciliary body and ciliary processes of the rabbit eye. Johns Hopk. Med. J. 125, 107–118 (1969a).

    Google Scholar 

  • —: A comparative study of the adrenergic innervation of the iris and ciliary structures in 18 species in phylogenesis. J. Morph. 128, 387–401 (1969b).

    Google Scholar 

  • Takáts, I.: Über den sympathikolytischen Einfluß des Dichlorisoproterenols am isolierten Katzenirissphincter. Albrecht v. Graefes Arch. Ophthal. 167, 474–482 (1964).

    Google Scholar 

  • Törnqvist, G.: Effect of cervical sympathetic stimulation on accomodation in monkeys. An example of a β-adrenergic inhibitory effects. Acta physiol. scand. 67, 363–373 (1966).

    Google Scholar 

  • —: The relative importance of the parasympathetic and sympathetic nervous systems for accomodation in monkeys. Invest. Ophthal. 6, 612–617 (1967).

    Google Scholar 

  • Tsukahara, S.: Histochemistry of catecholamine (CA) in the rabbit and human extraocular muscles. Jap. J. Ophthal. 12, 21–29 (1968).

    Google Scholar 

  • Weekers, R., Delmarcelle, Y., Gustin, J.: Treatment of ocular hypertension by adrenalin and diverse sympathomimetic amines. Amer. J. Ophthal. 40, 666–678 (1955).

    Google Scholar 

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  1. Departments of Experimental Ophthalmology and Histology, University of Lund, Lund, Sweden

    B. Ehinger

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Ehinger, B. A comparative study of the adrenergic nerves to the anterior eye segment of some primates. Z. Zellforsch. 116, 157–177 (1971). https://doi.org/10.1007/BF00331259

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