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Expression of fungal genes involved in penicllin biosynthesis

  • Special Topic Review: Control of Gene Expression Microorganisms. Edited by Miguel Vicente
  • Special Topic Review
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Abstract

Carbon catabolite repression and pH regulation are regulatory circuits with a wide domain of action in the Plectomycetes. Penicillin biosynthesis is one of the pathways which are under their control. The conclusions obtained so far, which are based on studies of the genetic and molecular regulation of the penicillin pathway of Aspergillus nidulans, would have been much harder to produce using an organism such as Penicillium chrysogenum (the industrial penicillin producer). However, A. nidulans and P. chrysogenum are close in terms of their phylogeny and one can reasonably predict that the conclusions about A. nidulans, which are summarized in this review and which are of unquestionable biotechnological relevance, will be extrapolable to the industrial organism.

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Authors and Affiliations

  1. Centro de Investigaciones Biológicas del C.S.I.C., Velázquez 144, 28006, Madrid, Spain

    M. A. Peñalva, E. Espeso, B. Pérez-Esteban, M. Orejas & J. M. Fernández-Cañón

  2. Departmento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, León, Spain

    H. Martínez-Blanco

Authors
  1. M. A. Peñalva
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  2. E. Espeso
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  3. B. Pérez-Esteban
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  4. M. Orejas
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  5. J. M. Fernández-Cañón
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  6. H. Martínez-Blanco
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Peñalva, M.A., Espeso, E., Pérez-Esteban, B. et al. Expression of fungal genes involved in penicllin biosynthesis. World Journal of Microbiology and Biotechnology 9, 461–467 (1993). https://doi.org/10.1007/BF00328034

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