Skip to main content
Log in

Studies on transvection at the bithorax complex in Drosophila melanogaster

  • Published:
Molecular and General Genetics MGG Aims and scope Submit manuscript

Summary

We have studied the influence of some mutations in the bithorax complex on the observed synapsis dependent phenotype of the genotypes Cbx 1Ubx1/+ and bx 34e/Ubx1. The effect of these mutations is similar to that introduced by disruption of pairing or by the z a mutation. Among the bx mutations, we find that bx 8 behaves differently from most other bx mutations in its influence on the synapsis dependent phenotype. This observation induced us to map the position of bx 8 with respect to other bx mutations; we find that it maps between bx 34e and bx 3. We show how some of the observations reported here can be fitted into a model of activation of the bithorax complex proposed by one of us.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Babu P, Bhat SG (1981) Role of zeste in transvection at the bithorax locus of Drosophila. Mol Gen Genet 183:400–402

    Google Scholar 

  • Banerji J, Olson L, Shaffner WA (1983) A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobin heavy chain genes. Cell 33:729–740

    Google Scholar 

  • Bender W, Akam M, Karch F, Beachy PA, Peifer M, Speirer P, Lewis EB, Hogness DS (1983) Molecular genetics of the bithorax complex in Drosophila melanogaster. Science 221:23–29

    Google Scholar 

  • Bender W, Weiffenbach B, Karch F, Peifer M (1985) Domains of Cis-interaction in the Bithorax Complex. Cold Spring Harbor Symp Quant Biol 50:173–180

    Google Scholar 

  • Davison D, Chapman CH, Wedeen C, Bingham PM (1985) Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and its synapsis dependent interactions in Drosophila adult tissues. Genetics 110:479–494

    Google Scholar 

  • Gelbart WM, Wu CT (1982) Interactions of Zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster. Genetics 102:179–189

    Google Scholar 

  • Lawrence P, Struhl G, Morata G (1979) Bristle patterns and compartment boundaries with tarsi of Drosophila. J Embryol Exp Morphol 51:195–208

    Google Scholar 

  • Lewis EB (1954) The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. Am Nat 88:225–239

    Google Scholar 

  • Lewis EB (1955) Some aspects of position pseudoallelism. Am Nat 89:73–89

    Google Scholar 

  • Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276:565–570

    Google Scholar 

  • Lewis EB (1980) New mutants. Dros Inf Service 55:207–208

    Google Scholar 

  • Lewis EB (1985) Regulation of the genes in the Bithorax Complex in Drosophila. Cold Spring Harbor Symp Quant Biol 50:155–164

    Google Scholar 

  • Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. Carnegie Inst Wash Publ 627

  • Modolell J, Bender W, Meselson M (1983) Drosophila melanogaster mutations supressible by the suppressor of Hairy-wing are insertions of a 7.3 kilobase mobile element. Proc Natl Acad Sci USA 80:1678–1682

    Google Scholar 

  • Morata G, Kerridge S (1980) An analysis of the expressivity of some bithorax transformations. In: Siddiqi O, Babu P, Hall LM, Hall JC (eds) Development and neurobiology of Drosophila. Plenum Press, New York London, p 141

    Google Scholar 

  • Zachar Z, Chapman CH, Bingham PM (1985) On the molecular basis of transvection effects and the regulation of transcription. Cold Spring Harbor Symp Quant Biol 50:337–346

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Communicated by J.A. Campos-Ortega

Rights and permissions

Reprints and permissions

About this article

Cite this article

Babu, P., Selvakumar, K.S. & Bhosekar, S. Studies on transvection at the bithorax complex in Drosophila melanogaster . Mol Gen Genet 210, 557–563 (1987). https://doi.org/10.1007/BF00327212

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00327212

Key words

Navigation