Summary
Twenty-five consecutive adult patients with acute lymphocytic leukaemia (ALL) all achieved complete remission, twenty-two with vincristine-prednisone, while thirteen patients also received daunorubicin (DNR). Three patients obtained remission only after treatment with cytosine arabinoside (Ara-C), 6 thioguanine (6-TG) and adriamycin (ADM). Despite central nervous system (CNS) prophylaxis by intraventricular injections via an Ommaya reservoir, 2/22 patients had a CNS relapse. The median remission duration of the whole group was 19 months. Four patients could stop therapy after 3 years. The median survival duration of all patients was 38 months. The quality of life of the patients during this chemotherapeutic regimen was good.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amadori S, Montuoro A, Meloni G, Spiriti MAA, Pacilli L, Mandelli F (1980) Combination chemotherapy for acute lymphocytic leukemia in adults. Am J Hematol 8: 175
Atkinson K, Wells DG, Clink HMD, Kay HEM, Powles R, McElwain TJ (1974) Adult acute leukaemia. Br J Cancer 30: 272
Aur RJA, Simone JV, Verzosa MS, Hustu HO, Basker LF, Pinkel DP, Rivera G, Dahl GV, Wood A, Stanger A, Mason C (1978) Childhood acute lymphocytic leukaemia. Cancer 42: 2133
Beard MEJ, Fairly GH (1974) Acute leukemia in adults. Semin Hematol 11: 5
Bennett JM, Catovsky D, Daniel M, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) British Co-operative Group. Proposals for the Classification of the Acute Leukaemias. Br J Haematol 33: 451
Conde E, Gonzalez F, Iriondo A, Recio M, Cuadrado MA, Zubizaretta A (1979) Acute lymphocytic leukemia with mediastinal involvement. Acta Haematol 62: 61
Cutler JS, Ederer F (1958) Maximum utilization of the life table method in analyzing survival. J Chronic Dis 8: 699
Einhorn LJ, Bond WH (1977) Remission induction with Daunomycin, Vincristine and Prednisone in adult acute lymphocytic leukemia. Oncology 34: 25
Gee TS, Haphbin M, Dowling MD, Cunningham I, Middleman MP, Clarkson BD (1976) Acute lymphoblastic leukemia in adults and children. Cancer 37: 1256
Gralnick HR, Galton DAG, Catovsky D, Sultan C, Bennett JM (1977) Classification of acute leukemia. Ann Intern Med 87: 740
Jacquillat C, Weil M, Gemon MF, Auder G, Loisel JP, Delobel J, Flandrin G, Schaisin G, Izrael V, Brussel A, Dresch C, Weisgerber C, Rain D, Tanzer J, Najean Y, Seligmann M, Boiron M, Benard J (1973) Combination therapy in 130 patients with acute lymphoblastic leukemia. Cancer Res 33: 3278
Lister TA, Whitehouse JMA, Beard MEJ, Brearley RL, Wrigley PFM, Oliver RTD, Freeman JE, Woodruff RK, Malpas JS, Paxton AN, Crowther D (1978) Combination chemotherapy for acute lymphoblastic leukaemia in adults. Br Med J 1: 199
Lister TA, Roberts MM, Brearley RL, Cullen MH, Greaves MF (1979) Prognostic factors in adult lymphoblastic leukemia III. In: Neth R, Gallo RC, Hofschneider PH, Mannweiler K (eds) Modern trends in human leukemia III. Springer, Berlin Heidelberg New York, p 99
Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 35: 1
Shaw MT, Raab SO (1977) Adriamycin in combination chemotherapy of adult acute lymphoblastic leukaemia. Med Pediatr Oncol 3: 261
Sleijfer DTh, Mulder NH, De Vries-Hospers HG, Fidler W, Van der Waaij D, Nieweg HO, Van Saene R (1980) Infection prophylaxis in granulocytopenic patients. Eur J Cancer 16: 859
Vellenga E, Mulder NH, Nieweg HO (1980) (Letter) Antithrombin III deficiency during asparaginase therapy. Lancet I: 649
Willemze R, Hillen H, Hartgrink-Groeneveld CA, Haanen C (1975) Treatment of acute lymphoblastic leukemia in adolescents and adults: A retrospective study in 41 patients (1970–1973). Blood 46: 823
Wolk RW, Masse SR, Conklin R, Freireich EJ (1974) The incidence of central nervous system leukemia in adults with acute leukemia. Cancer 33: 863
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
de Vries, E.G.E., Mulder, N.H., Houwen, B. et al. Combination chemotherapy for acute lymphocytic leukaemia in 25 adults. Blut 44, 151–158 (1982). https://doi.org/10.1007/BF00320761
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320761