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Inhibition by pesticides of prostaglandin formation in blood platelets

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Summary

Aggregation of human platelets was investigated after pre-incubation of platelet rich plasma with various pesticides of the carbamate type. Whereas N-methyl-carbamates (insecticides) inhibited the arachidonic acid induced aggregation, N-phenyl-carbamates (herbicides) had no effect. The influence of the different carbamates on aggregation coincided with their inhibition of thromboxane B2-formation. — DDE, a metabolite of the insecticide DDT, affected aggregation to a similar extent as N-methyl-carbamates. DDT, however, had no inhibitory activity.

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Abbreviations

ASA:

acetylsalicylic acid

AA:

arachidonic acid

DDT:

1,1,1-trichloro-2,2-bis-(p-chlorophenyl) ethane

DDE:

1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene

NMCs:

N-methyl-carbamates (insecticides)

NPCs:

N-phenyl-carbamates (herbicides)

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Authors and Affiliations

  1. Gesellschaft für Strahlen- und Umweltforschung München, Institute for Toxicology and Biochemistry, Ingolstädter Landstraße 1, D-8042, Neuherberg, Federal Republic of Germany

    H. F. Krug & J. Berndt

Authors
  1. H. F. Krug
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  2. J. Berndt
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Krug, H.F., Berndt, J. Inhibition by pesticides of prostaglandin formation in blood platelets. Blut 51, 19–23 (1985). https://doi.org/10.1007/BF00320596

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  • DOI: https://doi.org/10.1007/BF00320596

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