Summary
Eight cases of malignancies with concurrent motor neuron disease (MND), derived from an unselected population representing all cases of MND diagnosed during a 15-year period in two Italian provinces, were studied to verify the existence of paraneoplastic forms of the disease. No statistically significant association between the two diseases was found. Therefore, from our findings the occurrence of a neoplasm in a patient affected by MND can be considered a chance association.
This is a preview of subscription content, log in via an institution to check access.
References
Barron KD, Rodichok LD (1982) Cancer and disorders of motor neurons. In: Rowland LP (ed) Human motor neuron diseases. Raven Press, New York, pp 267–272
Barucha NE, Schoenberg BS, Raven RH, Pickle LV, Byar DP, Mason TJ (1983) Geographic distribution of motor neuron disease and correlation with possible etiologic factors. Neurology 33:911–915
Brain WR, Croft PB, Wilkinson M (1965) Motor neurone disease as a manifestation of neoplasm (with a note on the course of classical motor neurone disease). Brain 88:479–500
Branzaglia P, Camnasio M, Cantaboni A, Facchini U (1985) I tumori in Italia. Doctor 3:45–133
Buchanan DS, Malamud N (1973) Motor neuron disease with renal cell carcinoma and postoperative neurologic remission. A clinicopathological report. Neurology 23:891–895
Chiò A, Brignolio F, Meineri P, Rosso MG, Schiffer D (1988) Epidemiology of motor neuron disease in two Italian provinces. Analysis of secular trend and geographic distribution. Neuroepidemiology (in press)
Gubbay SS, Kahana E, Zilber N, Cooper G, Pintov S, Leibowitz Y (1985) Amyotrophic lateral sclerosis. A study of its presentation and prognosis. J Neurol 232:295–300
Hill ID (1972) Computing man-years at risk. Br J Prev Soc Med 26:132–134
Jokelainen M (1976) The epidemiology of amyotrophic lateral sclerosis in Finland. A study based on the death certificates of 421 patients. J Neurol Sci 29:55–63
Kondo K (1978) Motor neuron disease, changing population patterns and clues for etiology. In: Schoenberg BS (ed) Neurological epidemiology; priciples and clinical applications. Raven Press, New York, pp 509–542
Kondo K (1984) Motor neuron disease and Parkinson's disease are not associated with other disorders at autopsy. Neuroepidemiology 3:182–194
Norris FH, Engel WK (1965) Carcinomatous amyotrophic lateral sclerosis. In: Brain R, Norris FH Jr (eds) The remote effects of cancer on the nervous system. Grune and Stratton, New York, pp 24–41
Registro tumori per il Piemonte e la Valle d'Aosta (1985) Mortalità per tumori nella popolazione del Piemonte (1984) e la Valle d'Aosta (1980–84), Torino
Shy GM, Silverstein I (1965) A study of the effects upon the motor unit by remote malignancy. Brain 88:479–500
Author information
Authors and Affiliations
Additional information
This work was partly supported by CSI — Piemonte (Consorzio per il Sistema Informativo)
Rights and permissions
About this article
Cite this article
Chiò, A., Brignolio, F., Meineri, P. et al. Motor neuron disease and malignancies: results of a population-based study. J Neurol 235, 374–375 (1988). https://doi.org/10.1007/BF00314238
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00314238