Summary
Mixed haemagglutination and complement fixation tests were used to detect serum antibodies to peripheral nerve in 36 patients with acute Guillain-Barré syndrome. Twenty patients were treated with plasma exchange, 16 served as controls. A significant antibody titre was found in 19 patients with the haemagglutination test; 30 had complement-fixing antibodies. Patients lacking complement-fixing antibodies were less disabled at entry (P<0.01). However, there was no correlation between the course of the disease and any of the antibodies in the two patient groups. The two tests were therefore not able to select patients for treatment by plasma exchange.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Armitage P (1973) Statistical methods in medical research. Blackwell Scientific, Oxford, pp 119–122
Arnason BGW (1984) Acute inflammatory demyelinating polyradiculoneuropathies. In: Dyck PJ, Thomas PK, Lambert EH, Bunge R (eds) Peripheral neuropathy, vol 2. Saunders, Philadelphia, pp 2050–2100
Consensus Conference (1986) The utility of therapeutic plasmapheresis for neurological disorders. JAMA 256:1333–1337
Cook SD, Dowling PC, Murray MR, Whitaker JN (1971) Circulating demyelinating factors in acute idiopathic polyneuropathy. Arch. Neurol 24:136–144
Cooperative French Group (1984) Cooperative randomised trial of plasma exchange (P. E.) in Guillain-Barré syndrome (G. B. S.). Preliminary results. Ann Med Interne (Paris) 135:8
Färkkilä M, Kinnunen E, Haapanen E, Iivanainen M (1987) Guillain-Barré syndrome: Quantitative measurement of plasma exchange therapy. Neurology 37:837–840
Feasby TE, Hahn AF, Gilbert JJ (1982) Passive transfer studies in Guillain-Barré polyneuropathy. Neurology 32:1159–1167
Greenwood RJ, Newsom-Davis J, Hughes RAC, Aslan S, Bowden AN, Chadwick DW, Gordon NS, McLellan DL, Millac P, Stott RB, Armitage P (1984) Controlled trial of plasma exchange in acute inflammatory polyradiculoneuropathy. Lancet I:877–879
Guillain-Barré Syndrome Study Group (1985) Plasmapheresis and acute Guillain-Barré syndrome. Neurology 35:1096–1104
Harrison BM, Hansen LA, Pollard JD, McLeod JG (1984) Demyelination induced by serum from patients with Guillain-Barré syndrome. Ann Neurol 15:163–170
Koski CL, Humphrey R, Shin ML (1985) Anti-peripheral myelin antibody in patients with demyelinating neuropathy: quantitative and kinetic determination of serum antibody by complement component 1 fixation. Proc Natl Acad Sci 82:905–909
Koski CL, Gratz E, Sutherland J, Mayer RF (1986) Clinical correlation with anti-peripheral-nerve myelin antibodies in Guillain-Barré syndrome. Ann Neurol 19:573–577
Koski CL, Sanders M, Swoveland PT, Shin ML, Frank MM, Joiner K (1986) Quantitation of C9 neoantigen (Neo-C9) in the serum of patients with Guillain-Barré syndrome (GBS) and other demyelinating neuropathies. Neurology 36[Suppl 1]:304
Low PA, Schmelzer J, Dyck PJ, Kelly JJ Jr (1982) Endoneurial effects of sera from patients with acute inflammatory polyradiculoneuropathy: electrophysiologic studies on normal and demyelinated rat nerves. Neurology 32:720–724
Mancini G, Carbonara AO, Heremans JF (1965) Immunochemical quantification of antigens by single radial immunodiffusion. Immunochemistry 2:235–254
Melnick SC (1963) Thirty-eight cases of the Guillain-Barré syndrome: an immunological study. Br Med J I:368–373
NIH (1978) Diagnostic criterions for Gullain-Barré. JAMA 240:1709–1710
Nyland H, Aarli JA (1978) Guillain-Barré syndrome: demonstration of antibodies to peripheral nerve tissue. Acta Neurol Scand 58:35–43
Osterman PO, Fagius J, Lundemo G, Pihlstedt P, Pirskanen R, Sidén Å, Säfwenberg J (1984) Beneficial effects of plasma exchange in acute inflammatory polyradiculoneuropathy. Lancet II:1296–1299
Ryberg B (1980) Intrathecal and extrathecal production of antibrain antibodies in multiple sclerosis. J Neurol Sci 48:1–8
Ryberg B (1982) Antibrain antibodies in multiple sclerosis. J Neurol Sci 54:239–261
Ryberg B (1984) Extra- and intrathecal production of antinerve and antibrain antibodies in Guillain-Barré syndrome: evaluation by an antibody index. Neurology 34:1378–1381
Ryberg B, Hindfelt B, Nilsson B, Olsson J-E (1984) Antineural antibodies in Guillain-Barré syndrome and lymphocytic meningoradiculitis (Bannwarth's syndrome). Arch Neurol 41:1277–1281
Saida T, Saida K, Lisak RP, Brown MJ, Silberberg DH, Asbury AK (1982) In vivo demyelinating activity of sera from patients with Guillain-Barré syndrome. Ann Neurol 11:69–75
Tønder O, Morse PA Jr, Humphrey LJ (1974) Similarities of Fc receptors in human malignant tissue and normal lymphoid tissue. J Immunol 113:1162–1169
Valbonesi M, Garelli S, Mosconi L, Zerbi D, Celano I (1981) Plasma exchange as a therapy for Guillain-Barré syndrome with immune complexes. Vox Sang 41:74–78
Vedeler CA, Nyland H, Fagius J, Osterman PO, Matre R, Aarli JA, Janzen RWC, Jacobsen H, Skre H (1982) The clinical effect and the effect on serum IgG antibodies to peripheral nerve tissue of plasma exchange in patients with Guillain-Barré syndrome. J Neurol 228:59–64
Vedeler CA, Nyland H, Matre R (1982) Antibodies to peripheral nerve tissue in sera from patients with acute Guillain-Barré syndrome demonstrated by a mixed haemagglutination technique. J Neuroimmunol 2:209–214
Wesenberg F (1980) Tissue reactivity of IgG eluted from human carcinomas. Acta Pathol Microbiol Scand [C] 88:313–319
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Osterman, P.O., Vedeler, C.A., Ryberg, B. et al. Serum antibodies to peripheral nerve tissue in acute Guillain-Barré syndrome in relation to outcome of plasma exchange. J Neurol 235, 285–289 (1988). https://doi.org/10.1007/BF00314175
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00314175