Summary
Gliomatosis cerebri (syn. astrocytomatosis cerebri) is a rare diffuse neoplastic condition affecting all parts of the brain. The clinical and pathological features of an unusually diffuse and histologically uniform case of gliomatosis cerebri are presented. Many tumour cells stained positively for glial fibrillary acid protein, confirming the astrocytic derivation of this neoplasm. Differing views on the nature of gliomatosis cerebri are briefly discussed.
This is a preview of subscription content, log in via an institution to check access.
References
Artigas J, Cervos-Navarro J, Iglesias JR, Ebhardt G (1985) Gliomatosis cerebri: clinical and histological findings. Clin Neuropathol 4:135–148
Bebin J, Tytus JS (1956) Gliomatosis cerebri. Neurology 6:815–822
Blumbergs PC, Chin DKF, Hallpike JF (1983) Diffuse infiltrating astrocytoma (gliomatosis cerebri) with twenty-two-year history. Clin Exp Neurol 19:94–101
Couch JR, Weiss SA (1974) Gliomatosis cerebri: report of four cases and review of the literature. Neurology 24:504–511
Dahl D, Rueger DC, Bignami A, Weber K, Osborn M (1981) Vimentin, the 57000 molecular weight protein of fibroblast filaments, is the major cytoskeletal component in immature glia. Eur J Cell Biol 24:191–196
Dunn J, Kernohan JW (1956) Gliomatosis cerebri. AMA Arch Pathol 64:82–91
Ferraro A, Jervis GFA, Sherwood WD (1943) Patchy blastomatous infiltration of the central nervous system (Patchy schwannosis?). J Neuropathol Exp Neurol 2:207–225
Kawano N, Miyasaka Y, Yada K, Atari H, Sasaki K (1978) Diffuse cerebrospinal gliomatosis: case report. J Neurosurg 49:303–307
Malamud N, Wise BL, Jones OW (1952) Gliomatosis cerebri. J Neurosurg 9:409–417
Nevin S (1938) Gliomatosis cerebri. Brain 61:170–191
Pires M, Bonshek RE, Pilkington GJ (1987) Expression of the intermediate filament proteins, GFAP and vimentin in human gliomas. Neuropathol Appl Neurobiol (in press)
Russell DS, Rubinstein LJ (1977) Pathology of tumours of the nervous system. Arnold, Edinburgh
Sarhaddi S, Bravo E, Cyrus AE (1973) Gliomatosis cerebri: a case report and review of the literature. South Med J 66 (8):883–888
Scheinker IM, Evans JP (1943) Diffuse cerebral glioblastosis. J Neuropathol Exp Neurol 2:78–189
Simonati A, Vio M, Iannucci AM, Toso V, Morello F, Rizzuto N (1981) Gliomatosis cerebri diffusa. A case report. Acta Neuropathol (Berl) 54:311–314
Yung WK, Luna M, Borit A (1985) Vimentin and glial fibrillary acid protein in human brain tumours. J Neurooncol 3:35–38
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wilson, N.W., Symon, L. & Lantos, P.L. Gliomatosis cerebri: report of a case presenting as a focal cerebral mass. J Neurol 234, 445–447 (1987). https://doi.org/10.1007/BF00314097
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00314097