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Internuclear ophthalmoplegia, prenuclear paresis of contralateral superior rectus, and bilateral ptosis

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Summary

A patient with infarction of the paramedian part of the lower mid-brain on the right side is described, in whom internuclear ophthalmoplegia and bilateral ptosis were associated with limitation of elevation of the contralateral eye from paresis of the superior rectus. Supranuclear paresis was suggested by partial dissociation between phasic and tonic components of upward gaze. It is suggested that the right-sided lesion involved the rostral median longitudinal fasciculus before it reached the oculomotor nucleus, the central caudal nucleus medially situated in the lower end of the oculomotor nucleus, and the prenuclear fibres from the posterior commissure to the ipsilateral nucleus of the contralateral superior rectus. A supranuclear lesion may be suspected when there is a complex association of dysconjugate palsy of oculomotor muscles.

Zusammenfassung

Es wurde eine Patientin mit Infarkt des paramedianen Teils des unteren Mittelhirns rechts untersucht. Es lag eine internukleäre Ophthalmoplegie und eine bilaterale Ptose mit Heberschwäche des kontralateralen Auges bei Parese des M. rectus superior vor. Wegen einer partiellen Dissoziation von phasischen und tonischen Komponenten der Heberfunktion vermuteten wir eine supranukleäre Parese. Die Läsion umfaßt wahrscheinlich rechts das rostrale mediale Längsbündel, den zentralen caudalen Teil des Nucleus oculomotorius und die prenucleären Fasern der Commisura posterior.

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References

  1. Baker R (1981) Discussion summary. In: Fuchs E, Becker R (eds) Progress in oculomotor research. Elsevier/North-Holland, Amsterdam

    Google Scholar 

  2. Bender MB (1980) Brain control of conjugate horizontal and vertical eye movements. A survey of the structural and functional correlates. Brain 103:23–69

    Google Scholar 

  3. Bender MB, Weinstein EA (1943) Functional representation in the oculomotor and trochlear nuclei. Arch Neurol Psychiatry 49:98–106

    Google Scholar 

  4. Bini A, Paolella P (1968) Paralisi monoculare di elevazione. Un caso di sanguinamento postumo, traumatico mesencephalico. Riv Neurol 39:627–631

    Google Scholar 

  5. Boeder P (1961) The co-operation of the extraocular muscles. Am J Ophthalmol 51:469–481

    Google Scholar 

  6. Büttner-Ennever JA, Büttner U (1978) A cell group associated with vertical eye movements in the rostral reticular formation of the monkey. Brain Res 151:31–47

    Google Scholar 

  7. Büttner-Ennever JA, Büttner U, Cohen B, Baumgartner G (1982) Vertical gaze paralysis and the rostral interstitial nucleus of the medial longitudinal fasciculus (rostral iMLF). Brain 105:125–149

    Google Scholar 

  8. Caplan L (1980) “Top of the basilar” syndrome. Neurology (Minneap) 30:72–79

    Google Scholar 

  9. Carpenter MB (1971) Central oculomotor pathways. In: Bach-y-Rita P, Collins CC, Hyde JE (eds) The control of eye movements. Academic Press, New York, pp 67–103

    Google Scholar 

  10. Growdon JH, Winkler GF, Wray SF (1974) Midbrain ptosis. A case with clinicopathological correlation. Arch Neurol 30:179–181

    Google Scholar 

  11. Henn V, Büttner-Ennever JA, Hepp K (1982) The primate oculomotor system. I. Motoneurons. Hum Neurobiol 1:77–85

    Google Scholar 

  12. Hoyt CS (1979) Acquired “double elevator” palsy and polycythemia vera. J Pediatr Ophthalmol Strabismus 15:362–365

    Google Scholar 

  13. Jampel RS, Fells P (1968) Monocular elevation paresis caused by a central nervous system lesion. Arch Ophthalmol 80:45–57

    Google Scholar 

  14. Kirkham TH, Kline LB (1976) Monocular elevation paresis, Argyll Robertson pupils and sarcoidosis. Can J Ophthalmol 11:330–335

    Google Scholar 

  15. KÖmpf D (1982) Supranukleäre und internukleäre Augenbewegungen. Fortschr Neurol Psychiat 50:143–164

    Google Scholar 

  16. Lessel S (1975) Supranuclear paralysis of monocular elevation. Neurology (Minneap) 25:1134–1136

    Google Scholar 

  17. Malbran E, Norris AL (1955) Unilateral paralysis of the elevators of supranuclear origin. Br J Ophthalmol 39:73–84

    Google Scholar 

  18. Man HX (1967) A propos d'un cas de paralysis suprancléaire unilatérale des muscles élévateurs. Bull Soc Ophthalmol Fr 67:400–405

    Google Scholar 

  19. Meienberg O, Röver J, Kommerell G (1978) Prenuclear paresis of homolateral inferior rectus and contralateral superior oblique eye muscles. Arch Neurol 35:231–233

    Google Scholar 

  20. Metz HS (1979) Double elevator palsy. Arch Ophthalmol 97:901–903

    Google Scholar 

  21. Nutt A (1951) Congenital paralysis or paresis of the muscles used in elevation of the eye. Trans Ophthalmol Soc UK 71:389–400

    Google Scholar 

  22. Pierrot-Deseilligny C, Schaison M, Bousser MG, Brunet P (1981) Syndrome nucléaire du nerf moteur oculaire commun. Rev Neurol (Paris) 137:217–222

    Google Scholar 

  23. Pola J, Robinson DA (1978) Oculomotor signals in medial longitudinal fasciculus of the monkey. J Neurophysiol 41:245–259

    Google Scholar 

  24. Shanzer S, Goto K, Cohen B, Bender MB (1964) Median longitudinal fasciculus and vertical eye movements. Trans Am Neurol Assoc 89:255–256

    Google Scholar 

  25. Sieben G, De Reuck J, Vander Eecken H (1977) Thrombosis of the mesencephalic artery. Acta Neurol Belg 77:151–162

    Google Scholar 

  26. Smith JL, Cogan DG (1959) Internuclear ophthalmoplegia: a review of fifty-eight cases. Arch Ophthalmol 61:687–694

    Google Scholar 

  27. Szentagothai J (1964) Pathways and synoptic articulation patterns connecting vestibular receptors and oculomotor nuclei. In: Bender MB (ed) The oculomotor system. Hoeber Medical Division, New York, pp 205–223

    Google Scholar 

  28. Warwick R (1953) Representation of the extraocular muscles in the oculomotor nuclei of the monkey. J Comp Neurol 98:449–504

    Google Scholar 

  29. Yamamoto M, Shimoyama I, Highstein SM (1978) Vestibular nucleus neurons relaying excitation from the anterior canal to the oculomotor nucleus. Brain Res 148:31–42

    Google Scholar 

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Bogousslavsky, J., Regli, F., Ghika, J. et al. Internuclear ophthalmoplegia, prenuclear paresis of contralateral superior rectus, and bilateral ptosis. J Neurol 230, 197–203 (1983). https://doi.org/10.1007/BF00313631

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  • DOI: https://doi.org/10.1007/BF00313631

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