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Effects of angiotensin II and its blockers Sar1-lle8-angiotensin II and DuP 753 on drinking in ducks in relation to properties of subfornical organ neurons

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Abstract

Properties of systemically applied angiotensin II in stimulating water intake of normally hydrated ducks were studied and the results compared with properties of angiotensin II-responsive neurons of the subfornical organ which are considered as targets for circulating angiotensin, II acting as a dipsogen. Following intravenous infusion of hypertonic saline (2000 mosmol·kg-1 at 0.3 ml·min-1 for 1 h), intravenous infusion of 0.3 ml·min-1 isotonic saline with angiotensin II (200 ng·min-1), starting 1 h later, stimulated drinking in each case at an angiotensin II plasma level of about 1400 pg·ml-1. Without hypertonic priming, the same angiotensin II infusion did not stimulate drinking in each experiment; however, if effective, repeated infusions of ANGII induced stable dipsogenic responses. Angiotensin II infusions did not alter plasma levels of antidiuretic hormone. Sar1-Ile8-angiotensin II, a non-selective angiotensin II antagonist, acted weakly as a partial agonist when injused at a dose 200-fold higher than angiotensin II and effectively blocked the dipsogenic action of angiotensin II; this corresponds to the inhibition of angiotensin II-induced excitation by Sar1-Ile8-angiotensin II observed in duck subfornical organ neurons. DuP 753 (losartan), an angiotensin II antagonist specifically blocking AT1 receptors in mammals, had equivocal effects on angiotensin II-induced drinking in ducks at rates 50- and 200-fold higher than angiotensin II, which corresponds to the weak inhibitory action of this compound on angiotensin II-induced neuronal excitation in the duck SFO. Blood pressure was only marginally elevated by the applied angiotensin II dose and Sar1-Ile8-angiotensin II had no effect.

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Abbreviations

ANGII :

angiotensin II

AVT :

arginine vasotocin

DuP :

753 losartan

EDTA :

ethylene diamine tetra-acetic acid

HR :

heart rate

ICV :

intracerebroventricular

IV :

intravenous

MAP :

mean arterial pressure

SARILE :

Sar1-Ile8-angiotensin II

SFO :

subfornical organ

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Authors and Affiliations

  1. Max-Planck-Institute for Physiological and Clinical Research, W.G. Kerckhoff-Institute, Parkstrasse 1, D-61231, Bad Nauheim, Germany

    E. Simon & H. A. Schmid

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  1. E. Simon
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  2. H. A. Schmid
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Communicated by H. Langer

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Simon, E., Schmid, H.A. Effects of angiotensin II and its blockers Sar1-lle8-angiotensin II and DuP 753 on drinking in ducks in relation to properties of subfornical organ neurons. J Comp Physiol B 165, 607–614 (1996). https://doi.org/10.1007/BF00301128

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