Summary
Two patients with a Dq-chromosome are described. One had major somatic anomalies and one had minor somatic anomalies and bilateral retinoblastoma. Data from these patients is compared with that from 11 Dq- and 17 Dr cases in the literature. The association of Dq- with retinoblastoma is noted and the assignment of the retinoblastoma locus to a site on the proximal D long arm near the centromere is suggested. The possibility of a Dq-syndrome is discussed.
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The work is supported by The Spastics Society and the Medical Research Council.
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Taylor, A.I. Dq-, Dr and retinoblastoma. Hum Genet 10, 209–217 (1970). https://doi.org/10.1007/BF00295782
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DOI: https://doi.org/10.1007/BF00295782