Summary
Excretion and concentration of glycose aminoglycans were measured in 19 patients with frequent relapses of calcium-oxalate lithiasis, prior to and two weeks after onset of Diclofenac-Na therapy. In most patients, markedly anhanced glycose aminoglycan concentration and excretion could be demonstrated. Elevation of the high-molecular inhibitor potential in the urine results in reduced risk of calcium-oxalate lithogenesis, which may explain the therapeutic successe of nonsteroidal anti-inflammatory drugs in the treatment of therapy resistent calcium-oxalate lithiasis.
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Brundig, P., Börner, R.H., Haerting, R. et al. Glycose aminoglycane excretion and concentration in the urine of patients with frequently recurrent calcium-oxalate lithiasis prior to and following Diclofenac-Na therapy. Urol Res 18, 21–24 (1990). https://doi.org/10.1007/BF00294576
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DOI: https://doi.org/10.1007/BF00294576