Summary
The liver enzyme tyrosine aminotransferase (TAT; EC 2.6.1.5) catalyzes the rate-limiting step in the catabolic pathway of tyrosine. Deficiency in TAT enzyme activity underlies the autosomally inherited disorder tyrosinemia II (Richner-Hanhart syndrome). Using a human TAT cDNA clone as hybridization probe, we have determined the chromosomal location of the TAT structural gene by Southern blot analysis of DNAs from a series of human x rodent somatic cell hybrids. The results assign the TAT gene to human chromosome 16.
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Natt, E., Kao, FT., Rettenmeier, R. et al. Assignment of the human tyrosine aminotransferase gene to chromosome 16. Hum Genet 72, 225–228 (1986). https://doi.org/10.1007/BF00291882
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DOI: https://doi.org/10.1007/BF00291882