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Demonstration of Y/autosomal translocations using distamycin A

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Summary

The condensation of the brightly fluorescing Y-heterochromatin is prevented by cultivating leukocytes in a medium containing distamycin A. This technique provides a reliable method for the identification of those Y/autosomal translocations in which Y heterochromatin is involved. A case of a familiar Y/22 translocation and the distamycin A technique are described.

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  1. M. Schmid

    Present address: Institut für Humangenetik, University of Göttingen, Nikolausberger Weg 5a, D-3400, Göttingen, Federal Republic of Germany

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  1. Abteilung Humangenetik, Universität Ulm, Ulm, Germany

    M. Schmid

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  1. M. Schmid
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Schmid, M. Demonstration of Y/autosomal translocations using distamycin A. Hum Genet 53, 107–109 (1979). https://doi.org/10.1007/BF00289459

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  • DOI: https://doi.org/10.1007/BF00289459

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